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5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 11, 页码: 5387-5403
作者:
Wang, Jianfeng
;
Wang, Chen
;
Xu, Pan
;
Li, Xiao
;
Lu, Yongning
收藏
  |  
浏览/下载:131/0
  |  
提交时间:2021/05/24
clear cell renal cell carcinoma
protein arginine methyltransferase 1
therapeutic
lipocalin2 (LCN2)
sunitinib
Computational discovery and biological evaluation of novel inhibitors targeting histone-lysine N-methyltransferase SET7
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 卷号: 28, 期号: 7, 页码: 10
作者:
Min, Wenjian
;
Hou, Zeng
;
Zhang, Fang
;
Xie, Shengnan
;
Yuan, Kai
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
Histone methylation
Lysine methyltransferase
SET7
Small-molecule inhibitor
Virtual screening
The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:
Ye, Xiaoqing
;
Chen, Gang
;
Jin, Jia
;
Zhang, Binzhong
;
Wang, Yinda
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
WDR5
MLL1
histone methyltransferase
small-molecular inhibitor
epigenetics
human acute leukemia
In silico identification and structure function analysis of a putative coclaurine N-methyltransferase from Aristolochia fimbriata
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020, 卷号: 85
作者:
Ali, Roshan
;
Jiao, Yuannian
;
Wall, P. Kerr
;
Patching, Simon G.
;
Ahmad, Irshad
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/03/01
Coclaurine N-methyltransferase
Aristolochia fimbriata
Basal angiosperm
Aristolochic acid
Reaction mechanism
Homology model
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:
Shi, Yi
;
Ma, Hong-lei
;
Zhuang, You-wen
;
Wang, Xiao-xi
;
Jiang, Yi
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
PRC2
C10ORF12
H3K27me3
histone methyltransferase
epigenetic regulation
histone modification
Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia
期刊论文
BEHAVIOURAL BRAIN RESEARCH, 2019, 卷号: 364, 页码: 225-232
作者:
Kang, Yafei
;
Huang, Kexin
;
Lv, Yahui
;
Zhang, Wei
;
Cai, Suping
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/07/12
First episode schizophrenia
Catechol-O-methyltransferase
Dorsolateral prefrontal cortex
Resting state functional connectivity
Negative symptoms
Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
期刊论文
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17
作者:
Li, Fei
;
Wan, Xiaozhe
;
Xing, Jing
;
Tan, Xiaoqin
;
Li, Xutong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
deep neural network
virtual screening
methyltransferase
epigenetic
drug design
Simultaneous regulation of F5H in COMT-RNAi transgenic switchgrass alters effects of COMT suppression on syringyl lignin biosynthesis
期刊论文
PLANT BIOTECHNOLOGY JOURNAL, 2019, 卷号: 17, 期号: 4, 页码: 836-845
作者:
Wu, Zhenying
;
Wang, Nengfei
;
Hisano, Hiroshi
;
Cao, Yingping
;
Wu, Fengyan
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/08/19
caffeic acid O-methyltransferase
coordinated effects
ferulate 5-hydroxylase
lignin biosynthesis
Panicum virgatum L
switchgrass
Simultaneous regulation of F5H in COMT-RNAi transgenic switchgrass alters effects of COMT suppression on syringyl lignin biosynthesis
期刊论文
PLANT BIOTECHNOLOGY JOURNAL, 2019, 卷号: 17, 期号: 4, 页码: 836-845
作者:
Wu, Zhenying
;
Wang, Nengfei
;
Hisano, Hiroshi
;
Cao, Yingping
;
Wu, Fengyan
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2019/04/10
caffeic acid O-methyltransferase
coordinated effects
ferulate 5-hydroxylase
lignin biosynthesis
Panicum virgatum L
switchgrass
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