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Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4(+) and CD8(+) T cell responses 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 4
作者:  Choi, Il-Kyu;  Wang, Zhe;  Ke, Qiang;  Hong, Min;  Qian, Yu
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/04
EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma 期刊论文
CANCER LETTERS, 2016, 卷号: 380, 期号: 1
作者:  Lu, Jingchen;  Tang, Min;  Li, Hongde;  Xu, Zhijie;  Weng, Xinxian
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/05
EBV-LMP1 suppresses the DNA damage response through DNA-PK/AMPK signaling to promote radioresistance in nasopharyngeal carcinoma 期刊论文
Cancer Letters, 2016, 卷号: 380, 期号: 1, 页码: 191-200
作者:  Lu, Jingchen;  Tang, Min;  Li, Hongde;  Xu, Zhijie;  Weng, Xinxian
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/03
EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma 期刊论文
Oncotarget, 2015, 卷号: 6, 期号: 8, 页码: 5804-5817
作者:  Yang, Lifang;  Liu, Liyu;  Xu, Zhijie;  Liao, Weihua;  Feng, Deyun
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Interferon regulatory factor 7 is involved in the growth of Epstein Barr virus-transformed human B lymphocytes 期刊论文
VIRUS RESEARCH, 2015, 卷号: 195
作者:  Xu, Dongsheng;  Zhang, Yanyan;  Zhao, Lingjun;  Cao, Mingxia;  Lingel, Amy
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05
Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 卷号: 456, 期号: 3
作者:  Zhou, Heng;  Guo, Wei;  Long, Cong;  Wang, Huan;  Wang, Jingchao
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/05
Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity 期刊论文
Cancer Biology and Therapy, 2014, 卷号: 15, 期号: 1, 页码: 61-68
作者:  Yang, Lifang*;  Xu, Zhijie;  Liu, Liyu;  Luo, Xiangjian;  Lu, Jingchen
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
非特指性外周T细胞淋巴瘤中EBER、LMP1的表达及与预后的关系 期刊论文
临床与实验病理学杂志, 2014, 期号: 8
作者:  詹鹤琴;  朱雄增
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/19
Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文
International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118
作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03
DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.  
扁桃体弥漫大B细胞淋巴瘤的分型、预后及其与EB病毒的相关性研究 学位论文
2013
作者:  翟长文
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/19

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