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Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O-2 Sensitive Voltage-Gated K+ Channels
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 9
作者:
Fan, Fenling
;
Tian, Hua
;
Geng, Jie
;
Deng, Jizhao
;
Liu, Ya
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/11/19
Kv channel
EP4 receptor
O-2-sensitive Kv channel
prostanoids
IP receptor
pulmonary arterial hypertension
Beraprost
Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition
期刊论文
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 卷号: 126
作者:
Wang, Yanggan
;
Keskanokwong, Thitima
;
Cheng, Jun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
I-to channel
Kv4.3
Hypertrophy
Calcineurin
CaMKII
And myocytes
Silencing of KCNA1 suppresses the cervical cancer development via mitochondria damage
期刊论文
CHANNELS, 2019, 卷号: 13, 期号: 1, 页码: 321-330
作者:
Liu, Li
;
Chen, Yumei
;
Zhang, Qingyuan
;
Li, Changzhong
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/11
Voltage-gated potassium channel subfamily A member 1 (KCNA1/Kv1.1)
cervical cancer
Hedgehog (Hhg)
Wnt
Notch signaling pathway
Silencing of KCNA1 suppresses the cervical cancer development via mitochondria damage
期刊论文
Channels (Austin, Tex.), 2019, 卷号: 13, 期号: 1, 页码: 321-330
作者:
Liu L.
;
Chen Y.
;
Zhang Q.
;
Li C.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/11
cervical cancer
Hedgehog (Hhg)
Notch signaling pathway
Voltage-gated potassium channel subfamily A member 1 (KCNA1/Kv1.1)
Wnt
Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum
期刊论文
2019, 卷号: 21, 期号: 9, 页码: 887-894
作者:
Feng, Jia-Min
;
Li, Min
;
Zhao, Jin-Lian
;
Jia, Xiao-Na
;
Liu, Ji-Mei
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
Phenylspirodrimanes derivatives
Stachybotrys chartarum
potassium channel Kv1
3
Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions
期刊论文
PEPTIDES, 2018, 卷号: 108
作者:
Zhao, Yonghui
;
Xie, Zili
;
Feng, Jing
;
Li, Wenxin
;
Gao, Zhijian
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
beta-Defensin
Potassium channel
Kv1.3 channel
Pore-blocking
Interaction mode
Interaction mechanism
Mouse beta-Defensin 3, A Defensin Inhibitor of Both Its Endogenous and Exogenous Potassium Channels
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 6
作者:
Zhang, Yaoyun
;
Zhao, Yonghui
;
Liu, Hongyue
;
Yu, Weiwei
;
Yang, Fan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
potassium channel
vertebrate defensin
mouse beta-defensin 3
pharmacological feature
mouse Kv1.6 channel
inhibitor
A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis
期刊论文
CNS NEUROSCIENCE & THERAPEUTICS, 2018, 卷号: 24, 期号: 10
作者:
Yuan, Xiao-Lu
;
Zhao, Yi-Peng
;
Huang, Jie
;
Liu, Jun-Chen
;
Mao, Wen-Qian
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
EAE
immunomodulation
Kv1
3 channel
multiple sclerosis
neuroprotection
Formaldehyde regulates vascular tensions through nitric oxide-cGMP signaling pathway and ion channels
期刊论文
Chemosphere, 2018, 卷号: 193, 页码: 60-73
作者:
Zhang, Quanxi*
;
Tian, Peiru
;
Zhai, Miaomiao
;
Lei, Xiaodong
;
Yang, Zhenhua
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Formaldehyde
Thoracic aorta ring
Vascular tension
Ion channels
Signal pathway
4-AP
4-aminopyridine
ACh
acetylcholine
l-NAME
l
NG-nitro-l-arginine methyl ester
l
ACE
angiotensin-converting enzyme
VSMCs
vascular smooth muscle cells
BKCa
big-conductance Ca2+-activated K+ channel
FA
formaldehyde
IbTx
iberiotoxin
iNOS
inducible nitric oxide synthase
KATP
ATP-sensitive K+ channel
eNOS
endothelial nitric oxide synthase
Kv
voltage-dependent K+ channel
sGC
soluble guanylate cyclase
NE
norepinephrine
nNOS
neuronal nitric oxide synthase
NS-2028
4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
PGI2
prostacyclin
PKC
protein kinase C
cGMP
cyclic guanosine monophosphate
TEA
tetraethylammonium
The Kv1.3 channel-inhibitory toxin BF9 also displays anticoagulant activity via inhibition of factor XIa
期刊论文
TOXICON, 2018, 卷号: Vol.152, 页码: 9-15
作者:
Ding, Li
;
Hao, Jinbo
;
Luo, Xudong
;
Zhu, Wen
;
Wu, Zheng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/26
Kv1.3
channel
Factor
XIa
Structural
fold
Kunitz-type
Anticoagulation
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