×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [25]
北京大学 [18]
厦门大学 [14]
清华大学 [8]
金属研究所 [7]
西安交通大学 [6]
更多...
内容类型
期刊论文 [158]
会议论文 [1]
发表日期
2021 [4]
2019 [6]
2018 [14]
2017 [15]
2016 [10]
2015 [23]
更多...
学科主题
chemistry [3]
pharmacolo... [3]
Biochemist... [2]
Multidisci... [2]
Neuroscien... [2]
biochemist... [2]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共159条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
发表日期升序
发表日期降序
作者升序
作者降序
提交时间升序
提交时间降序
题名升序
题名降序
Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214, 页码: 16
作者:
Xu, Biao
;
Wang, Zhi-Peng
;
Liu, Qingwang
;
Yang, Xiaohong
;
Li, Xuemin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/17
Pyruvate dehydrogenase kinase
Proliferation
Cancer metabolism
Structure-activity relationship
Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 214
作者:
Xu, Biao
;
Wang, Zhi-Peng
;
Liu, Qingwang
;
Yang, Xiaohong
;
Li, Xuemin
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/04/26
Pyruvate dehydrogenase kinase
Proliferation
Cancer metabolism
Structure-activity relationship
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
DW14383 is an irreversible pan-FGFR inhibitor that suppresses FGFR-dependent tumor growth in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Dai, Meng-di
;
Wang, Yue-liang
;
Fan, Jun
;
Dai, Yang
;
Ji, Yin-chun
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
receptor tyrosine kinase
FGFR inhibitor
DW14383
antitumor activity
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
期刊论文
PSYCHOPHARMACOLOGY, 2019, 卷号: 236, 期号: 11, 页码: 3301-3315
作者:
Zhang, Sha-Sha
;
Tian, Yu-Hua
;
Jin, Song-Jun
;
Wang, Wen-Cheng
;
Zhao, Jing-Xin
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/09/21
Isoflurane
Rapid antidepressant activity
Chronic unpredictable mild stressed
Brain-derived neurotrophic factor
Tropomyosin receptor kinase B
Dendritic spine density
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Identification of new NIK inhibitors by discriminatory analysis-based molecular docking and biological evaluation
期刊论文
ARCHIV DER PHARMAZIE, 2019, 卷号: 352, 期号: 7, 页码: 9
作者:
Cheng, Gang
;
Mei, Xiao-Bing
;
Yan, You-You
;
Chen, Jing
;
Zhang, Bo
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
antiproliferation activity
inhibitors
NF-kappa B inducing kinase
virtual screen
A Convenient, Rapid, Sensitive, and Reliable Spectrophotometric Assay for Adenylate Kinase Activity.
期刊论文
Molecules (Basel, Switzerland), 2019, 卷号: Vol.24 No.4
作者:
Kai Song
;
Yejing Wang
;
Yu Li
;
Chaoxiang Ding
;
Rui Cai
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
adenylate
kinase
bromothymol
blue
enzymatic
activity
assay
orthogonal
experiment
spectrophotometry
Inhibition of Abl or Src tyrosine kinase decreased porcine circovirus type 2 production in PK15 cells.
期刊论文
Research in veterinary science, 2019, 卷号: 124, 页码: 1-9
作者:
Zhang, Jiaxin
;
Lei, Xinnuo
;
Wang, Dongliang
;
Jiang, Yifan
;
Zhan, Yang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/23
Antiviral activity
PK15 cells
Porcine circovirus 2
Tyrosine kinase inhibitor STI-571 and PP2
Virus like particles
©版权所有 ©2017 CSpace - Powered by
CSpace