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科研机构
昆明植物研究所 [1]
湖南大学 [1]
湖南中医药大学 [1]
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期刊论文 [3]
发表日期
2013 [2]
2012 [1]
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Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Mechanism research of anti-arterial thrombosis of Dahuang Zhechong Wan screened by Ti-Al intermetallic compound porous material
期刊论文
China Journal of Traditional Chinese Medicine and Pharmacy, 2013, 卷号: Vol.28 No.12, 页码: 3649-3653
作者:
Wan Ling
;
Wang Zhanyi
;
Wei Xing
;
Li Jiyang
;
Zhong Guangwei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/05
Ti-Al intermetallic compound porous materials (TAICPM)
Refined Dahuang Zhechong Wan
Arterial thrombosis
Isolated Chinese medicine
Mechanism of anti-arterial thrombosis of Dahuangzhecong Fang screened by Ti-Al intermetallic compound porous material
期刊论文
Transactions of Nonferrous Metals Society of China, 2012, 卷号: 22, 期号: 12, 页码: 3156-3160
作者:
Wan Ling
;
Wang Zhan-yi
;
Wei Xing
;
Li Ji-yang
;
Zhong Guang-wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/27
Ti-Al intermetallic compound porous materials
Dahuangzhecong Fang
arterial thrombosis
isolated Chinese medicine
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