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南华大学 [1]
西安交通大学 [1]
四川大学 [1]
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湖南农业大学 [1]
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期刊论文 [6]
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2016 [1]
2015 [1]
2012 [1]
2009 [2]
2008 [1]
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Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor kappaB pathway.
期刊论文
Nutrition Research, 2016, 卷号: 36, 期号: 7, 页码: 648-657
作者:
Sun, Xiaohong
;
Chakrabarti, Subhadeep
;
Fang, Jun
;
Yin, Yulong
;
Wu, Jianping*
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/23
Ovomucin hydrolysate
Inflammation
Dermal fibroblast
Desalting
NF-κB
Ultrafiltration
BAY 11-7085
(E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile
CBB
Coomassie Brilliant Blue
HDFs
human dermal fibroblasts
IκBα
inhibitor κBα
ICAM-1
intercellular cell adhesion molecule-1
MW
molecular weight
NF-κB
nuclear factor κ–light-chain-enhancer of activated B cells
PAGE
polyacrylamide gel electrophoresis
SDS
sodium dodecyl sulfate
TNF
tumor necrosis factor
TFA
trifluoroacetic acid
UPLC
ultra-performance liquid chromatograph
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:
Zhang, Lei
;
Xu, Xuan
;
Yang, Ruhao
;
Chen, Jingwen
;
Wang, Shixuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However
the underlying molecular mechanism remains unclear. In this study
we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3
and inhibited the expression of fibronectin
alpha-smooth muscle actin (α-SMA)
and collagen I in cultured NRK-49F cells. S3I-201
an STAT3 inhibitor
also suppressed the expression of fibronectin
α-SMA
and collagen I in cultured NRK-49F cells. Mechanistically
paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore
paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin
α-SMA
and collagen I
and suppressed the infiltration of macrophages and production of TNF-α
IL-1β
TGF-β
and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation
consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis
and inhibition of proinflammatory cytokine production.
Psychological stress, immune response, and atherosclerosis
期刊论文
Atherosclerosis, 2012, 卷号: 223, 期号: 1, 页码: 69-77
作者:
Gu, Hong-feng*
;
Tang, Chao-ke
;
Yang, Yong-zong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/27
Psychological stress
Toll-like 4
NF-κB
Cytokines
Innate immune
Atherosclerosis
HPA
hypothalamic-pituitary-adrenal
SAM
sympathetic-adrenal-medullary
SNS
sympathetic nervous system
Th1, Th2
T helper cell type1, T helper cell type 2
NE
norepinephrine
CRF
corticotropin-releasing factor
POMC
proopiomelanocortin
ACTH
adrenocorticotropic hormone
α-MSH
alpha melanocyte-stimulating hormone
CNS
central nervous system
CRP
C-reactive protein
CD
cluster of differentiation
NK
natural killer
CMV
cytomegalovirus
HSV
herpes simplex virus
VZV
varicella zoster virus
IL-1, IL-4, IL-6, IL-8, IL-10
interleukin-1, interleukin-4, interleukin-6, interleukin-8, interleukin-10
NF-κB
nuclear factor-κB
PBMCs
peripheral blood monocytes
apoE−/− mice
apolipoprotein E knockout mice
LDL
low-density lipoprotein
TLRs, TLR4
Toll-like receptors, Toll-like receptor 4
PRRs
pattern-recognition receptors
SRs
scavenger receptors
oxLDL
oxidized low density lipoprotein
PAMPs
pathogen-associated molecular patterns
PNI
psychoneuroimmunology
GC
glucocorticoid
MR
mineraloreceptor
GR
glucocorticoid receptor
TNF-α
tumor necrosis factor-alpha
LPS
lipopolysaccharide
APPs
acute phase proteins
APR
acute phase response
HSP
heat shock protein
EDA
extra domain A
DAMPs
damage-associated molecular patterns
siRNA
small interfering RNA
MAPKs
mitogen activated protein kinases
MyD88
myeloid differentiation factor-88
TRIF
TIR domain-containing adapter protein inducing IFN-β
ACS
acute coronary syndrome
CHD
coronary heart disease
M-CSF
macrophage-colony-stimulating factor
ICAM-1
intercellular adhesion molecule-1
VCAM-1
vascular cell adhesion molecule-1
MMPs
matrix-degrading matrix metalloproteinases
β-AR
beta-adrenergic receptor
CI
confidence interval
Anti-inflammatory effect of the polysaccharides of Golden needle mushroom in burned rats
期刊论文
International Journal of Biological Macromolecules, 2009
-
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/03/05
Agaricales/*chemistry
Animals
Anti-Inflammatory
Agents/*therapeutic
use
Antigens,
CD4/blood
Antigens,
CD8/blood
Burns/blood/*drug
therapy/enzymology
Chromatography,
High
Pressure
Liquid
Colon/metabolism
Intercellular
Adhesion
Molecule-1/blood
Interleukin-10/blood
Magnetic
Resonance
Spectroscopy
Male
Molecular
Weight
Peroxidase/blood
Polysaccharides/*therapeutic
use
Rats
Rats,
Wistar
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection
期刊论文
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2009, 卷号: 29, 期号: 2, 页码: 173-176
作者:
Li, Congsheng
;
Niu, Xiaolin
;
Lei, Cong
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/18
Keshan disease
Coxsackie B virus
soluble intercellular adhesion molecule-1
cardiac function
soluble vascular cell adhesion molecular-1
Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer
期刊论文
EUROPEAN JOURNAL OF CANCER, 2008, 卷号: 44, 期号: 16, 页码: 2425-2432
作者:
Liu, Yunfang
;
Yu, Huiming
;
Zhang, Cheng
;
Chen, Yufeng
;
Hu, Likuan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/27
Non-small cell lung cancer
Radiation-induced lung injury
Berberine
Intercellular adhesion molecular-1
Transforming growth factor-beta-1
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