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Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor kappaB pathway. 期刊论文
Nutrition Research, 2016, 卷号: 36, 期号: 7, 页码: 648-657
作者:  Sun, Xiaohong;  Chakrabarti, Subhadeep;  Fang, Jun;  Yin, Yulong;  Wu, Jianping*
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/23
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
Psychological stress, immune response, and atherosclerosis 期刊论文
Atherosclerosis, 2012, 卷号: 223, 期号: 1, 页码: 69-77
作者:  Gu, Hong-feng*;  Tang, Chao-ke;  Yang, Yong-zong
收藏  |  浏览/下载:11/0  |  提交时间:2019/12/27
Psychological stress  Toll-like 4  NF-κB  Cytokines  Innate immune  Atherosclerosis  HPA  hypothalamic-pituitary-adrenal  SAM  sympathetic-adrenal-medullary  SNS  sympathetic nervous system  Th1, Th2  T helper cell type1, T helper cell type 2  NE  norepinephrine  CRF  corticotropin-releasing factor  POMC  proopiomelanocortin  ACTH  adrenocorticotropic hormone  α-MSH  alpha melanocyte-stimulating hormone  CNS  central nervous system  CRP  C-reactive protein  CD  cluster of differentiation  NK  natural killer  CMV  cytomegalovirus  HSV  herpes simplex virus  VZV  varicella zoster virus  IL-1, IL-4, IL-6, IL-8, IL-10  interleukin-1, interleukin-4, interleukin-6, interleukin-8, interleukin-10  NF-κB  nuclear factor-κB  PBMCs  peripheral blood monocytes  apoE−/− mice  apolipoprotein E knockout mice  LDL  low-density lipoprotein  TLRs, TLR4  Toll-like receptors, Toll-like receptor 4  PRRs  pattern-recognition receptors  SRs  scavenger receptors  oxLDL  oxidized low density lipoprotein  PAMPs  pathogen-associated molecular patterns  PNI  psychoneuroimmunology  GC  glucocorticoid  MR  mineraloreceptor  GR  glucocorticoid receptor  TNF-α  tumor necrosis factor-alpha  LPS  lipopolysaccharide  APPs  acute phase proteins  APR  acute phase response  HSP  heat shock protein  EDA  extra domain A  DAMPs  damage-associated molecular patterns  siRNA  small interfering RNA  MAPKs  mitogen activated protein kinases  MyD88  myeloid differentiation factor-88  TRIF  TIR domain-containing adapter protein inducing IFN-β  ACS  acute coronary syndrome  CHD  coronary heart disease  M-CSF  macrophage-colony-stimulating factor  ICAM-1  intercellular adhesion molecule-1  VCAM-1  vascular cell adhesion molecule-1  MMPs  matrix-degrading matrix metalloproteinases  β-AR  beta-adrenergic receptor  CI  confidence interval  
Anti-inflammatory effect of the polysaccharides of Golden needle mushroom in burned rats 期刊论文
International Journal of Biological Macromolecules, 2009
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收藏  |  浏览/下载:3/0  |  提交时间:2019/03/05
Circulating adhesion molecules in patients with Keshan disease and their relationship with Coxsackie B virus infection 期刊论文
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2009, 卷号: 29, 期号: 2, 页码: 173-176
作者:  Li, Congsheng;  Niu, Xiaolin;  Lei, Cong
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/18
Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer 期刊论文
EUROPEAN JOURNAL OF CANCER, 2008, 卷号: 44, 期号: 16, 页码: 2425-2432
作者:  Liu, Yunfang;  Yu, Huiming;  Zhang, Cheng;  Chen, Yufeng;  Hu, Likuan
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/27


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