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An unexpected new pathway for nitroxide radical production via more reactve nitrogen-centered amidyl radical intermediate during detoxification of the carcinogenic halogenated quinones by N-alkyl hydroxamic acids
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 146, 页码: 150-159
作者:
Zhu, Ben-Zhan
;
Xu, Dan
;
Qin, Li
;
Huang, Chun-Hua
;
Xie, Lin-Na
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/09/14
N-centered amidyl radical
Nitroxide radical
Hydrogen-abstraction
Tetrachloroquinoid compounds
N-alkyl hydroxamic acids
Unexpected activation of N-alkyl hydroxamic acids to produce reactive N-centered free radicals and DNA damage by carcinogenic chlorinated quinones under normal physiological conditions
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 146, 页码: 70-78
作者:
Huang, Chun-Hua
;
Xu, Dan
;
Qin, Li
;
Tang, Tian-Shu
;
Shan, Guo-Qiang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/09/14
N-alkyl hydroxamic acids
N-centered radicals
Chlorinated quinones
Carbon-nitrogen bonding conjugate
DNA adducts
Recent advances in the discovery of potent and selective HDAC6 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 1406-1418
作者:
Wang, Xiu-Xiu
;
Wan, Ren-Zhong
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HDAC6
HDAC6 inhibitors
Zinc binding groups
Hydroxamic acids
Sulfur
containing ZBGs
An Unusual Double Lossen Rearrangement Reaction: The Novel Molecular Detoxication Mechanism for Hydroxamic Acids
期刊论文
ACTA CHIMICA SINICA, 2015, 卷号: 73, 期号: 8, 页码: 765-769
作者:
Zhu Benzhan
;
Shao Bo
;
Li Feng
;
Liu Yuxiang
;
Huang Chunhua
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2016/03/10
Lossen rearrangement
tetrachloro-1
hydroxamic acids
2
hydrolysis
4-benzoquinone
5-dichloro-3
6-dihydroxy-1
4-benzoquinone
Repurposing of HDAC inhibitors toward anti-hepatitis C virus drug discovery: teaching an old dog new tricks
期刊论文
Future medicinal chemistry, 2015, 卷号: 7, 期号: 11, 页码: 1367-1371
作者:
Zhao, Fabao
;
Liu, Na
;
Zhan, Peng
;
Liu, Xinyong
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/17
cheminformatics
direct-acting antiviral drugs
drug repurposing
hepatitis C virus
histone deacetylase inhibitors
host cellular factors
hydroxamic acids
Inhibition and Mechanism of HDAC8 Revisited
期刊论文
journal of the american chemical society, 2014
Chen, Kai
;
Zhang, Xiaoxiao
;
Wu, Yun-Dong
;
Wiest, Olaf
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  |  
浏览/下载:4/0
  |  
提交时间:2015/11/11
HISTONE DEACETYLASE INHIBITORS
AB-INITIO QM/MM
ZINC-BINDING GROUPS
ACTIVE-SITE
CATALYTIC-ACTIVITY
CRYSTAL-STRUCTURE
HYDROXAMIC ACIDS
CANCER-THERAPY
PROTEIN
TSA
An efficient method for the preparation of hydroxamic acids
期刊论文
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2013, 卷号: 90, 期号: 3, 页码: 381-385
作者:
Gao, XA
;
Wang, XX
;
Yan, H
;
Li, J
;
Yan, RL
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  |  
浏览/下载:3/0
  |  
提交时间:2016/03/29
Hydroxamic acids
carboxylic acids
acyl chlorides
hydroxylamine hydrochloride
Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors
期刊论文
Bioorganic and Medicinal Chemistry Letters, 2013, 卷号: 23, 期号: 11, 页码: 3200-3203
作者:
Zhou, Ming
;
Ning, Chengqing
;
Liu, Ruihuan
;
He, Yujun
;
Yu, Niefang*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
HDAC
Histone deacetylases
Hydroxamic acids
Indeno[1,2-d]thiazole
Tricyclic
A Simple Method for the Isolation and Purification of 2,4-Dihydroxy-7-Methoxy-2H-1,4-Benzoxazin-3(4H)-One (DIMBOA) from Maize (Zea mays L.) Seedlings
期刊论文
Journal of Integrative Agriculture, 2013, 卷号: 12, 期号: 1, 页码: 95-102
作者:
Li Jing
;
Liu Xingang
;
Dong Fengshou
;
Xu Jun
;
Guo Liqun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2016/12/06
DIMBOA
maize
isolation
purification
hydroxamic acids
Transition-Metal-Free Electrophilic Amination of Arylboroxines
期刊论文
organic letters, 2012
Xiao, Qing
;
Tian, Leiming
;
Tan, Renchang
;
Xia, Ying
;
Qiu, Di
;
Zhang, Yan
;
Wang, Jianbo
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2015/11/11
N BOND FORMATION
C-H BONDS
CROSS-COUPLING REACTIONS
DIORGANOZINC REAGENTS
AEROBIC DIOXYGENATION
CATALYZED AMINATION
CARBON-HETEROATOM
HYDROXAMIC ACIDS
ROOM-TEMPERATURE
SINGLE-ELECTRON
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