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科研机构
北京大学 [4]
中国医学科学院 北京... [4]
上海药物研究所 [1]
辽宁师范大学 [1]
昆明动物研究所 [1]
内容类型
期刊论文 [11]
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2019 [2]
2017 [1]
2015 [1]
2013 [1]
2012 [2]
2011 [1]
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Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands
期刊论文
2019, 卷号: 29, 期号: 12, 页码: 1541-1545
作者:
Zhu, Mei
;
Dong, Biao
;
Zhang, Guo-Ning
;
Wang, Ju-Xian
;
Cen, Shan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
Purine bases
HIV-1 protease inhibitors
Biological evaluation
Design, synthesis and biological evaluation of novel HIV-1 protease inhibitors with pentacyclic triterpenoids as P2-ligands
期刊论文
2019, 卷号: 29, 期号: 3, 页码: 357-361
作者:
Zhu, Mei
;
Du, Xiao-Nan
;
Li, Yun-Ge
;
Zhang, Guo-Ning
;
Wang, Ju-Xian
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
HIV-1 protease inhibitors
P2 ligand
Pentacyclic triterpenoids
Design and synthesis of potent HIV-1 protease inhibitors with (S)-tetrahydrofuran-tertiary amine-acetamide as P2-ligand: Structure-activity studies and biological evaluation
期刊论文
2017, 卷号: 137, 页码: 30-44
作者:
Bai Xiaoguang
;
Yang Zhiheng
;
Zhu Mei
;
Dong Biao
;
Zhou Lei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/04
HIV-1 protease
Inhibitors
P2 ligand
Enzyme
Design
Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands
期刊论文
2015, 卷号: 25, 期号: 9, 页码: 1880-1883
作者:
Yang, Zhi-Heng
;
Bai, Xiao-Guang
;
Zhou, Lei
;
Wang, Ju-Xian
;
Liu, Hong-Tao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/13
HIV-1 protease
Inhibitors
HAART
Darunavir
A comprehensive analysis of the influence of drug binding kinetics on drug action at molecular and systems levels
期刊论文
分子生物系统, 2013
Yin, Ning
;
Pei, Jianfeng
;
Lai, Luhua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/10
HIV-1 PROTEASE INHIBITORS
NF-KAPPA-B
RESIDENCE TIME
DISCOVERY
MECHANISMS
TRANSIENT
DYNAMICS
ONSET
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 5, 页码: 1976-1979
作者:
Yan, Jianwei
;
Huang, Ning
;
Li, Shukun
;
Yang, Liu-Meng
;
Xing, Weiqiang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
HIV-1 protease inhibitors
Amprenavir
Darunavir biaryl compounds
Docking study
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 卷号: 22, 期号: 5, 页码: 1976-1979
作者:
Yan JW
;
Huang N
;
Li SK
;
Yang LM
;
Xing WQ
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2012/03/19
HIV-1 protease inhibitors
Amprenavir
Darunavir biaryl compounds
Docking study
Elucidating the Energetics of Entropically Driven Protein-Ligand Association: Calculations of Absolute Binding Free Energy and Entropy
期刊论文
journal of physical chemistry b, 2011
Deng, Nan-jie
;
Zhang, Peng
;
Cieplak, Piotr
;
Lai, Luhua
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/11/12
HUMAN-IMMUNODEFICIENCY-VIRUS
MOLECULAR-DYNAMICS SIMULATIONS
HIV-1 PROTEASE
DRUG DESIGN
COMPUTER-SIMULATIONS
ACCURATE PREDICTION
STRUCTURAL BIOLOGY
EXPLICIT SOLVENT
WATER-MOLECULES
INHIBITORS
An estimation method of binding free energy in terms of ABEEMsigmapi/MM and continuum electrostatics fused into LIE method
期刊论文
Journal of Computational Chemistry, 2010
作者:
Chen SL
;
Zhao DX
;
Yang ZZ.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/27
Acquired
Immunodeficiency
Syndrome/drug
therapy
HIV
Protease/chemistry/*metabolism
HIV-1/*enzymology
Humans
Hydrogen
Bonding
Models,
Molecular
Protease
Inhibitors/chemistry/*pharmacology
Protein
Binding
Static
Electricity
Thermodynamics
The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase
期刊论文
生物化学与生物物理学研究通讯, 2006
Wei, P
;
Fan, KQ
;
Chen, H
;
Ma, L
;
Huang, CK
;
Tan, L
;
Xi, D
;
Li, CM
;
Liu, Y
;
Cao, AN
;
Lai, LH
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/11
SARS coronavirus
3C-like proteinase
mutational study
N-terminal peptide
dimerization inhibitor
peptide inhibitor
Zhang-Poorman plot
ACUTE-RESPIRATORY-SYNDROME
LINKED INTERFACIAL PEPTIDES
SMALL-MOLECULE INHIBITORS
HIV-1 PROTEASE
MAIN PROTEASE
ANALYTICAL ULTRACENTRIFUGATION
HUMAN-IMMUNODEFICIENCY
CRYSTAL-STRUCTURES
VIRUS PROTEASES
3CL PROTEASE
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