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Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer
期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
作者:
Li N(李宁)
;
Zhang XY(张晓宇)
;
Zhou J(周瑾)
;
Li W(李旺)
;
Shu XY(舒芯钰)
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/10/23
Liver tissue stiffness
Shear stress
Hydrostatic pressure
Hepatocytes
Hepatocellular carcinoma
Liver sinusoidal endothelial cells
Hepatic stellate cells
Mechanotransduction pathways
Mechanomedicine
Drug design and delivery
Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy
期刊论文
STEM CELL RESEARCH & THERAPY, 2021, 卷号: 12, 期号: 1, 页码: 12
作者:
Ma, Chen
;
Zhang, Ludi
;
He, Ting
;
Cao, Huiying
;
Ren, Xiongzhao
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/12/01
Raman spectroscopy
Cell therapy
Identification
Proliferating human hepatocytes
Dedifferentiation
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Circadian gene Clock participates in mitochondrial apoptosis pathways by regulating mitochondrial membrane potential, mitochondria out membrane permeablization and apoptosis factors in AML12 hepatocytes
期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020, 卷号: 467, 期号: 1-2, 页码: 65-75
作者:
Yang, Shuhong
;
Liu, Yanyou
;
Guo, Yimei
;
Liu, Rong
;
Qi, Fang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/03/01
Clock
Apoptosis
Hepatocytes
Bcl-2 family proteins
Mitochondrial membrane potential
Mitochondria out membrane permeablization
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 3, 2020, 卷号: 320, 页码: G272-G282
作者:
Li W(李旺)
;
Li PW(李培文)
;
Li N(李宁)
;
Du Y(杜宇)
;
Lv SQ(吕守芹)
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2022/10/25
hepatocytes
liver fibrosis
matrix stiffness
shear flow
three-dimensional liver sinusoidal model
Nimesulide increases the aldehyde oxidase activity of humans and rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Zhou, Lei
;
Pang, Xiao-yan
;
Hou, Xiang-yu
;
Liu, Lu
;
Guo, Zi-tao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
nimesulide
aldehyde oxidase
induction
methotrexate
hepatocytes
pharmacokinetics
drug interaction
Understanding the Multiple Effects of PCBs on Lipid Metabolism
期刊论文
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2020, 卷号: 13, 页码: 3691-3702
作者:
Shan, Qiuli
;
Li, Hongmei
;
Chen, Ningning
;
Qu, Fan
;
Guo, Jing
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2021/09/14
PCBs
metabolism-disrupting chemicals
hepatocytes
lipid metabolism
Responses of catalase and superoxide dismutase to low-dose quantum dots on molecular and cellular levels
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 181, 页码: 388-394
作者:
Zhao, Lining
;
Guo, Dandan
;
Lin, Jing
;
Liu, Rutao
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/08/19
MPA-CdSe/ZnS QDs
Oxidative stress
Hepatocytes
Catalytic enzymes
Molecular mechanisms
基于胚胎干细胞模型研究环境污染物对神经肝脏发育的干扰效应
学位论文
北京: 中国科学院生态环境研究中心, 2019
作者:
梁胜贤
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  |  
浏览/下载:4/0
  |  
提交时间:2020/07/17
环境污染物, 胚胎干细胞, 神经发育 毒性,肝 脏发育 毒性
Environmental Pollutants, Embryonic Stem Cells, Developmental Neural Toxicity, Developmental Hepatocytes Toxicity
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