IMM-H007  Cordycepin derivative  Endothelial dysfunction  Vascular inflammation  AMP-activated protein kinase  Endothelial nitric oxide synthase  

Ergosterol monoester derivatives  Anti-tumor activity in vivo  H&  E  TUNEL  Immunohistochemistry  Western blot  

4E-BP1  4E binding protein  AMPK  AMP-activated protein kinase  ATF6  activating transcription factor 6  ATP  adenosine triphosphate  DEPTOR  DEP domain containing mTOR-interacting protein  CI  complexes I  CII  complex II  CIII  complex III  CIV  complex IV  CV  complex V  eIF2α  Eukaryotic Initiation Factor 2α  ER  Endoplasmic Reticulum  ERAD  ER-associated degradation  ERO1α  ER oxidoreductase 1 α  FoxO1  Forkhead box O1  GβL  G Protein β Subunit Like Protein  GRP78  78 kDa glucose-regulated protein precursor  GSIS  glucose-stimulated insulin secretion  IRE1  Inositol-requiring enzyme 1  IRS1  Insulin receptor substrate 1  IRS2  Insulin receptor substrate 2  mLST8  mammalian lethal with sec-13 protein 8  mSin1  the mammalian stress-activated MAP kinase-interaction protein 1  mtDNA  mitochondrial deoxyribonucleic acid  mTOR  mammalian TOR  mTORC1  mTOR complex 1  mTORC2  mTOR complex 2  NADPH oxidase  Nicotinamide adenine dinucleotide phosphate-oxidase  NOS  nitric oxide synthase  O2–·  superoxide anion  H2O2  hydrogen peroxide  OH·  hydroxyl radical  3O2  triplet-state molecular oxygen  OXPHOS  oxidative phosphorylation  CAT  catalase  GPx  glutathioneperoxidase  PERK  Protein kinase R-like endoplasmic reticulum kinase  PDI  ER protein disulfide isomerases  PI3K  the phosphoinositide3-kinase  PRAS40  40-kDa proline-rich Akt substrate  PRAS40  the 40-kDa proline-rich Akt substrate  PROTOR  the protein observed with RICTOR  RAPTOR  regulatory-associated protein of mTOR  RICTOR  The rapamycin-insensitive companion of mTOR  REDD1  DNA damage response 1  RNS  reactive nitrogen species  ROS  reactive oxygen species  RNS  reactive nitrogen species  S6K  S6 kinase  SOD  superoxidedismutase  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TOR  the target of rapamycin  TSC2  Tuberous sclerosis 2  UPR  unfolded protein response  Mitochondrial oxidative stress  ER stress  mTOR  Pancreatic β cells  

天然药物  调血脂作用  新结构新靶标化合物IMM-H007  AMP激活的蛋白激酶  创新药物研究开发  

IR  insulin resistance  WT  wild type  KO  knockout  TG  transgenic  NTG  non-transgenic  NC  normal chow  HFD  high-fat diet  PPARα  peroxisome proliferator-activated receptor alpha  ECM  extracellular matrix  NL  normal liver  NAFLD  non-alcoholic fatty liver disease  H&E  hematoxylin and eosin  ALT  alanine transaminase  AST  aspartate transaminase  ALP  alkaline phosphatase  HMGCR  3-hydroxy-3-methyl-glutaryl-CoA reductase  LDL  low density lipoprotein  HDL  high density lipoprotein  LDLR  low-density lipoprotein receptor  GPAT  glycerol-3-phosphate acyltransferase  DGAT  diglyceride acyltransferase  FFA  free fatty acid  SREBP1c  sterol response element binding protein 1c  ACC  acetyl-CoA carboxylase  FAS  fatty acid synthase  SCD  stearoyl-CoA desaturase  LXR-α  liver X receptor-α  ARG-1  arginase-1  ABCA  ATP-binding cassette transporter A  ABCG  ATP-binding cassette transporter G  CYP7A1  cytochrome P450, family 7, subfamily A, polypeptide 1  AMPK  AMP-activated protein kinase  IL  interleukin  TNF-α  tumor necrosis factor alpha  MCP-1  monocyte chemoattractant protein 1  MRC1  mannose receptor, C type 1  MGL  macrophage galactose-type C-type lectin  JNK  Jun N-terminal kinase  FBG  fasting glucose  HOMA-IR  homeostasis model assessment of insulin resistance  GTT  glucose tolerance test  ITT  intraperitoneal insulin tolerance test  Fins  fasting insulin  shRNA  short hairpin RNA  GFP  green fluorescent protein  IRS  insulin receptor substrate  Akt  protein kinase B  HSL  hormone sensitive lipase  ATGL  adipose triacylglycerol lipase  ACOX  acyl-coenzyme A oxidase  CPT-1α  carnitine palmitoyltransferase-1-α  LCAD  long-chain acyl-CoA dehydrogenase  MCAD  medium-chain acyl-CoA dehydrogenase  UCP  uncoupling protein  FGF21  fibroblast growth factor  PPRE  peroxisome proliferators response element  AUC  area under the curve  IKKβ  inhibitor of nuclear factor kappa B kinase beta subunit  Spondin 2  Fatty liver  Insulin resistance  PPARα