中国开放科研知识云: 检索

Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment 期刊论文
2018, 卷号: 15, 期号: 4, 页码: 443-451
作者: Wang, Jing; Zhao, Yizhuo; Wang, Qiming; Zhang, Li; Shi, Jianhua

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Non-small cell lung cancer anlotinib prognostic factor analysis third- or further-line therapy

Mid-late Pleistocene glacial evolution in the Grove Mountains, East Antarctica, constraints from cosmogenic Be-10 surface exposure dating of glacial erratic cobbles 期刊论文
QUATERNARY SCIENCE REVIEWS, 2016, 卷号: 145, 期号: 0, 页码: 71-81
作者: Dong, GC (Dong, Guocheng); Huang, FX (Huang, Feixin); Caffee, MW (Caffee, Marc W.); Huang, FX; Yi, CL (Yi, Chaolu)

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Glacial HisTories From The East Antarctic Ice Sheet (Eais) Provide Keys To UnderstAndIng Correlations Between The Eats And Global Climate. They Are Especially Helpful In The Assessment Of Global Sea Level Change And As a Means Of Quantifying The Magnitude Of pAst Glacial Activity And The RAte At Which Ice Responded To climAte Change. Given The Significance Of Eais Glacial hisTories It Is Imperative That More Glacial Chronologic Data For thIs Region Be Obtained Especially For The Mid-to-lAte Pleistocene. We Report Cosmogenic Be-10 Surface Exposure DAtIng Results From Glacially Transported Cobbles Embedded In Blue-ice moraIne MAterial At Mount hardIng The Grove Mountains Eais. Forty Exotic Cobbles Sampled AlOng Two PrOfiles (a And b) On This Blue-ice MoraIne Present Apparent Exposure-ages RangIng From 7.2 To 542.2 Ka. We Explore This Scattered Dataset By UsIng PrIncipal compOnent Analysis (Pca) To Identify Statistically Significant Trends In The Data. We Identify a correlatiOn betWeen Exposure-age And Distance Of The Cobbles From Mount hardIng. In prOfile a Cobbles Further From Mount HardIng Yield Older Exposure-ages Than Those That Are Relatively Close. In Profile b Cobbles Closer To Mount HardIng Are Found To Have Relatively Older Exposure-ages. In Term Of Glacial hisTory We Suggest That The Direction Of Ice Flow Changed durIng The Period From Similar To 60 To 200 Ka And That Multiple Glacial Fluctuations Occurred In The Mid-late Pleistocene. (c) 2016 Elsevier Ltd. All Rights Reserved.

Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians 期刊论文
NEUROLOGICAL SCIENCES, 2015, 卷号: 36, 期号: 1
作者: Chuan, Lixue; Gao, Jie; Lei, Yuying; Wang, Raoxiang; Lu, Lechun

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Catechol-O-methyltransferase Parkinson's disease Polymorphism Further analysis Asian

Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua

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2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.

沉积物暴露条件下文蛤 Meretrix meretrix 对重金属 Cu、Pb的富集动力学研究 期刊论文
热带海洋学报, 2013, 期号: 1, 页码: 70-75
作者: 李磊[1]; 王云龙[2]; 沈盎绿[3]; 蒋玫[4]; 黄厚见[5]

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文蛤重金属生物富集动力学沉积物暴露 of heavy metals Cu and Pb in M. meretrix but requires further experimental research and analysis under different conditions. :Meretrix meretrix heavy metal bioaccumulation kinetics sediment exposure

Research on energy characteristics of aerospace relay mirror system (EI CONFERENCE) 会议论文
2011 International Conference on Electronic and Mechanical Engineering and Information Technology, EMEIT 2011, August 12, 2011 - August 14, 2011, Harbin, China
Liu C.; Zhong X.; Piao Y.; Jin G.

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Aerospace Relay Mirror System (ARMS) as a new concept weapon used in reflection of High Energy Laser (HEL) in space is studied. It extends the attacking range of Ground Based Laser (GBL) weapons enormously. Relevant researches have been carried out for many years. The structures and operating theory of the entire system consists of ground-based high energy laser weapon and space-based relay mirror. The main work of this study is focused on the analysis of relay mirror energy characteristics to deduce the relationship among the attacking range of weapon and diameter of ARMS and target irradiance. Calculation examples are also given. The results proved the strong points and feasibility of ARMS theoretically further. It is summarized that more importance should be attached to ARMS development. The results given in this paper can be reference of an actual ARMS system to some extends. 2011 IEEE.

The new approach for infrared target tracking based on the particle filter algorithm (EI CONFERENCE) 会议论文
International Symposium on Photoelectronic Detection and Imaging 2011: Advances in Infrared Imaging and Applications, May 24, 2011 - May 24, 2011, Beijing, China
Sun H.; Han H.-X.

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Target tracking on the complex background in the infrared image sequence is hot research field. It provides the important basis in some fields such as video monitoring precision and video compression human-computer interaction. As a typical algorithms in the target tracking framework based on filtering and data connection the particle filter with non-parameter estimation characteristic have ability to deal with nonlinear and non-Gaussian problems so it were widely used. There are various forms of density in the particle filter algorithm to make it valid when target occlusion occurred or recover tracking back from failure in track procedure but in order to capture the change of the state space it need a certain amount of particles to ensure samples is enough and this number will increase in accompany with dimension and increase exponentially this led to the increased amount of calculation is presented. In this paper particle filter algorithm and the Mean shift will be combined. Aiming at deficiencies of the classic mean shift Tracking algorithm easily trapped into local minima and Unable to get global optimal under the complex background. From these two perspectives that "adaptive multiple information fusion" and "with particle filter framework combining" we expand the classic Mean Shift tracking framework.Based on the previous perspective we proposed an improved Mean Shift infrared target tracking algorithm based on multiple information fusion. In the analysis of the infrared characteristics of target basis Algorithm firstly extracted target gray and edge character and Proposed to guide the above two characteristics by the moving of the target information thus we can get new sports guide grayscale characteristics and motion guide border feature. Then proposes a new adaptive fusion mechanism used these two new information adaptive to integrate into the Mean Shift tracking framework. Finally we designed a kind of automatic target model updating strategy to further improve tracking performance. Experimental results show that this algorithm can compensate shortcoming of the particle filter has too much computation and can effectively overcome the fault that mean shift is easy to fall into local extreme value instead of global maximum value.Last because of the gray and fusion target motion information this approach also inhibit interference from the background ultimately improve the stability and the real-time of the target track. 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

The study of encoding principle and encoding disc design of a new-style vernier absolute encoder (EI CONFERENCE) 会议论文
2nd Annual Conference on Electrical and Control Engineering, ICECE 2011, September 16, 2011 - September 18, 2011, Yichang, China
Ai H.; Li L.

收藏 | 浏览/下载：20/0 | 提交时间：2013/03/25

To satisfy the requirement of encoder miniaturization high dependability and high measuring accuracy a new-style vernier absolute type encoder which offered significant advantages over less reticling circles and high precision was presented in the paper which carried out the design of vernier encoding disc the analysis of new-style vernier encoding principle and exact encoding track calibration by studying the photoelectric encoder. The Matlab simulation results prove that the encoding and coding methods are feasible. The test showed that the cubage of encoder was quite small and the diameter of the encoder can be controlled within 100mm its resolution can reach 24 bits i.e. 0.0772. The feasibility of encoding and coding method was further proved. 2011 IEEE.

The effectiveness of real-time embedded software testing (EI CONFERENCE) 会议论文
2011 9th International Conference on Reliability, Maintainability and Safety: Safety First, Reliability Primary, ICRMS'2011, June 12, 2011 - June 15, 2011, Guiyang, China
Zhang B.; Shen X.

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Real-time embedded software is widely applied in the fields with high reliability and security like aviation and space flight etc. In those systems software quality is of vital importance and software testing as a means of guaranteeing the quality of software is gaining increasingly more attention. The effectiveness of software testing enables people to gain confidence in software correctness. The real-time and embedding features of embedded software lead to the particularity in real-time embedded software testing. On the basis of particularity analysis of embedded software testing the author of this thesis further conducted research on the effective Software Testing and proved that it is valid to adopt testing techniques and strategies through experiments. 2011 IEEE.

Proteomic analysis of cold stress responses in tobacco seedlings 期刊论文
African Journal of Biotechnology, 2011, 卷号: 10, 期号: 82, 页码: 18991-19004
作者: Jin, Yan; Zhang, Caohao; Yang, Hui; Yang, Yuhong; Huang, Chengjiang

收藏 | 浏览/下载：3/0 | 提交时间：2019/12/23

Cold stress is one of the major abiotic stresses limiting the productivity and the geographical distribution of many important crops. To gain a better understanding of cold stress responses in tobacco (Nicotiana tabacum) we carried out a comparative proteomic analysis. Five-week-old tobacco seedlings were treated at 4°C for 4 h. Cold treatment resulted in stress phenotypes of smoothing and shallowing leaves and increased relative electrolyte leakage. The expression changes of total proteins in tobacco leaves were examined using two-dimensional electrophoresis. Quantitative image analysis revealed a total of 101 protein spots that changed their intensities significantly 21 protein spots were down-regulated eight were up-regulated after the cold treatment 50 protein spots only expressed in the control sample while 22 protein spots were only present in the cold treatment sample. Mass spectrometry analysis allowed the identification of 73 differentially expressed proteins including well known and novel cold-responsive proteins. The identified proteins are involved in several processes such as photosynthesis protein processing redox homeostasis ribonucleic acid (RNA) processing signal transduction translation cell division/cycle and metabolisms of carbon and energy. Several types of proteins showed enhanced degradation during chilling stress especially the photosynthetic proteins. Gene expression analysis of 25 different proteins by reverse transcriptase- polymerase chain reaction (RT-PCR) showed that the messenger RNA (mRNA) levels of 18 genes correlated well with the protein levels. In conclusion our study provides new insights into cold stress responses in tobacco and needs to be further studied in future.

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