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上海药物研究所 [11]
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复旦大学上海医学院 [3]
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期刊论文 [29]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 20
作者:
Chen, Jingjing
;
Li, Yalei
;
Zhang, Jie
;
Zhang, Minmin
;
Wei, Aihuan
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
HDAC
BRD4
Selective dual inhibitors
Anticancer
Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2019, 卷号: 11, 期号: 15, 页码: 1849-1852
作者:
Liang, Xuewu
;
Liu, Hong
;
Zhang, Yingjie
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
dual inhibitors
HDAC
hematological malignancies
JAK
multiple target drugs
Novel-targeted therapy for hematological malignancies with JAK and HDAC dual inhibitors
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2019, 卷号: 11, 期号: 15, 页码: 1849-1852
作者:
Liang, Xuewu
;
Liu, Hong
;
Zhang, Yingjie
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/11
dual inhibitors
HDAC
hematological malignancies
JAK
multiple target
drugs
Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016?2019)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 11, 页码: 871-879
作者:
Dong, Yue
;
Zhao, Tong
;
Ai, Wei
;
Zalloum, Waleed A.
;
Kang, Dongwei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
URAT1 inhibitors
lesinurad
RDEA3170
SHR4640
benzbromarone
sulfonamide
dual inhibitor
gout
hyperuricemia
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 17, 页码: 3836-3845
作者:
Gao, Ping
;
Cheng, Xiqiang
;
Sun, Lin
;
Song, Shu
;
Alvarez, Mar
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
HIV-1
RNase H
Integrase
Dual inhibitors
Design and Synthesis of Arylamidine Derivatives as Serotonin/Norepinephrine Dual Reuptake Inhibitors
期刊论文
2019, 卷号: 24, 期号: 3
作者:
Wen, Hui
;
Qin, Wen
;
Yang, Guangzhong
;
Guo, Yanshen
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
serotonin
norepinephrine
dual reuptake inhibitors
antidepressant
Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 14, 页码: 1682-1702
作者:
Wang, Xueshun
;
Gao, Ping
;
Menendez-Arias, Luis
;
Liu, Xinyong
;
Zhan, Peng
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
AIDS
HIV-1
RNase H inhibitors
dual inhibitors
drug design
SAR
antiviral
metalloenzyme
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724
作者:
Sun, Lin
;
Gao, Ping
;
Dong, Guanyu
;
Zhang, Xujie
;
Cheng, Xiqiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HAART
HIV-1 dual inhibitors
HIV-1 IN
RNase H
5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives
Privileged
structure
Novel Dual Inhibitors of Secretory Phospholipase A(2) and Sphingomyelin Synthase: Design, Synthesis and Evaluation
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 卷号: 13, 期号: 10
作者:
Gong, Haojun
;
Zhou, Lu
;
Ye, Deyong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/06
Atherosclerosis
secretory phospholipase A(2) (sPLA(2))
sphingomyelin synthase (SMS)
dual inhibitors
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