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Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer
期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
作者:
Li N(李宁)
;
Zhang XY(张晓宇)
;
Zhou J(周瑾)
;
Li W(李旺)
;
Shu XY(舒芯钰)
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/10/23
Liver tissue stiffness
Shear stress
Hydrostatic pressure
Hepatocytes
Hepatocellular carcinoma
Liver sinusoidal endothelial cells
Hepatic stellate cells
Mechanotransduction pathways
Mechanomedicine
Drug design and delivery
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
Structural basis for the inhibition of SARS-CoV2 main protease by Indian medicinal plant-derived antiviral compounds
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 页码: 9
作者:
Saravanan, Konda Mani
;
Zhang, Haiping
;
Senthil, Renganathan
;
Vijayakumar, Kevin Kumar
;
Sounderrajan, Vignesh
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  |  
浏览/下载:121/0
  |  
提交时间:2020/12/10
SARS-CoV2
main protease
medicinal plants
molecular docking and dynamics
drug design
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16
作者:
Tan, Xiaoqin
;
Jiang, Xiangrui
;
He, Yang
;
Zhong, Feisheng
;
Li, Xutong
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  |  
浏览/下载:37/0
  |  
提交时间:2020/12/21
Schizophrenia
Multitarget antipsychotic drugs
Recurrent neural network
Multitask deep neural network
Automated drug design
Conceptual design and multifield coupling behavior of magnetically propelled fish-like swimmers
期刊论文
Smart Materials and Structures, 2020, 卷号: 11, 期号: 29
作者:
Gao W(高伟)
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  |  
浏览/下载:8/0
  |  
提交时间:2020/11/13
Biomimetics
Composite structures
Conceptual design
Drug delivery
Electromagnetic field effects
Intelligent robots
Particle reinforced composites
Biomimetic robot fishes
Comsol multiphysics
Ferromagnetic particles
Fluid-solid coupling
Multi-field coupling
Numerical research
Sensitive materials
Spatial arrangements
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
先导化合物结构优化策略七肽类分子结构修饰与改造
期刊论文
药学学报, 2020, 卷号: 55, 期号: 3, 页码: 427
作者:
彭晶晶
;
王江
;
戴文豪
;
谢雄
;
柳红
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
peptide
structure optimization
drug design
lead compound
多肽
结构改造
药物设计
先导化合物
A smart bioresponsive nanosystem with dual-modal imaging for drug visual loading and targeted delivery
期刊论文
CHEMICAL ENGINEERING JOURNAL, 2020, 卷号: 391
作者:
Peng, Jingyi
;
Gong, Peiwei
;
Li, Shuohan
;
Kong, Fei
;
Ge, Xingxing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/11/25
Structure design
FRET
Drug visual loading
Targeted delivery
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
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