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Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:243/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
收藏
  |  
浏览/下载:241/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Prognostic value of ATAD3 gene cluster expression in hepatocellular carcinoma
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 2
作者:
Yang, Burong
;
Yu, Tingdong
;
Ye, Qiuwen
;
Ai, Liang
;
Li, Gang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/04
mRNA expression
ATPase family AAA domain-containing protein 3
hepatocellular carcinoma
prognosis
MiR-873-5p suppresses cell proliferation and epithelial-mesenchymal transition via directly targeting Jumonji domain-containing protein 8 through the NF-κB pathway in colorectal cancer.
期刊论文
Journal of cell communication and signaling, 2019
作者:
Wang Liqiang
;
Jiang Fuquan
;
Ma Feng
;
Zhang Bin
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/05
Colorectal cancer (CRC)
Epithelial–mesenchymal transition (EMT)
Nuclear factor kappa beta (NF-κB) pathway
Umonji domain-containing protein 8 (JMJD8)
miR-873-5p
ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 卷号: 43, 期号: 2
作者:
Sun, Xuan
;
Li, Wei
;
Wang, Daguang
;
Zhang, Yang
;
Wang, Lei
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
gastric cancer
lymph node metastasis
disintegrin and metalloproteinase domain-containing protein 17
prognostic factor
signaling pathway
Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis
期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2019, 卷号: 16, 期号: 8
作者:
Wu, Weijun
;
Qin, Ming
;
Jia, Wanwan
;
Huang, Zheng
;
Li, Zhongzheng
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/12/05
cystathionine-gamma-lyase
rheumatoid arthritis
Jumonji domain-containing protein 3
Sp-1
Toll like receptor 2
Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis
期刊论文
CELLULAR & MOLECULAR IMMUNOLOGY, 2019, 卷号: 16, 期号: 8
作者:
Wu, Weijun
;
Qin, Ming
;
Jia, Wanwan
;
Huang, Zheng
;
Li, Zhongzheng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/12/05
cystathionine-gamma-lyase
rheumatoid arthritis
Jumonji domain-containing protein 3
Sp-1
Toll like receptor 2
Dengue Virus M Protein Promotes NLRP3 Inflammasome Activation To Induce Vascular Leakage in Mice
期刊论文
JOURNAL OF VIROLOGY, 2019, 卷号: 93, 期号: 21
作者:
Pan, Pan
;
Zhang, Qi
;
Liu, Weiyong
;
Wang, Wenbiao
;
Lao, Zizhao
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
DENV membrane protein
M
dengue virus
DENV
interleukin-1 beta
IL-1 beta
NLRP3 inflammasome
Nod-like receptor (NLR) family pyrin domain containing 3
NLRP3
vascular leakage
vascular permeability
NOD2 Promotes Dopaminergic Degeneration Regulated by NADPH Oxidase 2 in 6-Hydroxydopamine Model of Parkinson\'s Disease
期刊论文
神经药理学报, 2019, 期号: 04, 页码: 27
作者:
CHENG Li
;
CHEN Lin
;
WEI Xin-bing
;
WANG Yi-meng
;
REN Zhi-ping
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
nucleotide-binding oligomerization domain-containing protein 2(NOD2)
neuroinflammation
microglia
cytokine
apoptosis
reactive oxygen species(ROS)
NADPH oxidase 2(NOX2)
Parkinson\'s disease
Expression patterns and the prognostic value of the SMYD family members in human breast carcinoma using integrative bioinformatics analysis
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 17, 期号: 4, 页码: 3851-3861
作者:
Song, Jianping
;
Liu, Yanfeng
;
Chen, Qian
;
Yang, Jinhuan
;
Jiang, Zhengchen
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Suppressor of variegation
Enhancer of Zeste
Trithorax and
Myeloid-Nervy-DEAF1 domain-containing protein
breast carcinoma
prognosis
bioinformatic analyses
transcription
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