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科研机构
复旦大学上海医学院 [5]
中南大学 [1]
武汉大学 [1]
昆明医科大学 [1]
湖南大学 [1]
内容类型
期刊论文 [8]
图书章节 [1]
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2018 [1]
2016 [2]
2014 [2]
2013 [1]
2012 [3]
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OTUB1 protein suppresses mTOR complex 1 activity by deubiquitinating the mTORC1 inhibitor DEPTOR
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: Vol.293 No.13, 页码: 4883-4892
作者:
Zhao, LL
;
Wang, XB
;
Yu, Y
;
Deng, L
;
Chen, L
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/26
cancer
biology
cell
signaling
deubiquitylation
(deubiquitination)
protein
stability
tumor
cell
biology
DEPTOR
OTU
domain-containing
ubiquitin
aldehyde-binding
protein
1
(OTUB1)
mTORC1
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
DEPTOR suppresses the progression of esophageal squamous cell carcinoma and predicts poor prognosis
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 12
作者:
Ji, Yan-Mei
;
Zhou, Xue-Feng
;
Zhang, Jun
;
Zheng, Xiang
;
Li, Sheng-Bao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
DEPTOR
mTOR
esophageal squamous cell carcinoma
proliferation
DEPTOR Expression Negatively Correlates with mTORC1 Activity and Tumor Progression in Colorectal Cancer
期刊论文
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 卷号: 15, 期号: 11
作者:
Lai, Er-Yong
;
Chen, Zhen-Guo
;
Zhou, Xuan
;
Fan, Xiao-Rong
;
Wang, Hua
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/04
Colorectal cancer
mTOR
DEPTOR
P-S6
immunohistochemistry
Induction of Protective Autophagy in Cancer Cells by NAE Inhibitor MLN4924
图书章节
2014
作者:
Jiang, Yanan/56939172000[0]
;
Jia, Lijun/26653512000[1]
;
Sun, Yi/55520058800[2]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
Anticancer therapy
Autophagy in tumorigenesis
DEPTOR
MLN4924-induced autophagy
Neddylation
Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells
期刊论文
CELL DEATH AND DIFFERENTIATION, 2013, 卷号: 20, 期号: 2
作者:
Yang, D.
;
Li, L.
;
Liu, H.
;
Wu, L.
;
Luo, Z.
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/19
ROC1
Cullin-RING ligase
autophagy
senescence
Deptor
Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells
期刊论文
AUTOPHAGY, 2012, 卷号: 8, 期号: 11
作者:
Luo, Zhongguang
;
Pan, Yongfu
;
Jeong, Lak Shin
;
Liu, Jie
;
Jia, Lijun
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/19
Cullin-RING E3 ligase
SKP1-Cullin-F-box (SCF) E3 ligase
neddylation
NEDD8-activating enzyme
MLN4924
autophagy
DEPTOR
MTOR
Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis
期刊论文
CELL DEATH & DISEASE, 2012, 卷号: 3
作者:
Zhao, Y.
;
Xiong, X.
;
Jia, L.
;
Sun, Y.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/19
autophagy
Cullin neddylation
DEPTOR
HIF1 alpha
mTOR
CRL E3 ligases
Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis
期刊论文
AUTOPHAGY, 2012, 卷号: 8, 期号: 12
作者:
Yang, Dongqin
;
Zhao, Yongchao
;
Liu, Jie
;
Sun, Yi
;
Jia, Lijun
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/19
ROC1
RBX1
Cullin-RING E3 ligase
autophagy
senescence
DEPTOR
MTOR
neddylation
MLN4924
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