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浏览/检索结果: 共8条，第1-8条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Fluorometric determination of RNase H via a DNAzyme conjugated to reduced graphene oxide, and its application to screening for inhibitors and activators 期刊论文 Microchimica Acta, 2019, 卷号: Vol.186 No.6 作者:  Chunyi Tong;  Ting Zhou;  Chuan Zhao;  Liqun Yuan;  Ying Xu 收藏  |  浏览/下载：30/0  |  提交时间：2019/12/17 Fluorescent probe  Nanomaterial  Signal amplification  Quenching efficiency  Tumor cell lines  High sensitivity  Concentration-dependent manner  Model docking  Kinetic analysis  Hepatitis C virus   Fluorometric determination of RNase H via a DNAzyme conjugated to reduced graphene oxide, and its application to screening forinhibitors and activators 期刊论文 MICROCHIMICA ACTA, 2019, 卷号: Vol.186 No.6 作者:  Tong, CY;  Zhou, T;  Zhao, C;  Yuan, LQ;  Xu, Y 收藏  |  浏览/下载：17/0  |  提交时间：2019/12/17 Fluorescent probe  Nanomaterial  Signal amplification  Quenching efficiency  Tumor cell lines  High sensitivity  Concentration-dependent manner  Model docking  Kinetic analysis  Hepatitis C virus   Tofacitinib ameliorates atherosclerosis and reduces foam cell formation in apoE deficient mice 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017 Wang, Zaicun; Wang, Shumei; Wang, Zunzhe; Yun, Tiantian; Wang, Chenchen; Wang, Huating 收藏  |  浏览/下载：2/0  |  提交时间：2017/12/03 Tofacitinib  Atherosclerosis  Macrophage  Inflammation  Foam cell formation  PATHWAY-DEPENDENT MANNER  ABCA1 EXPRESSION  APOLIPOPROTEIN-E  JAK INHIBITOR  DIFFERENTIATION  MACROPHAGES  SUPPRESSORS  ACTIVATION   Effects of patulin on the proliferation and apoptosis of human embryonic kidney cells 期刊论文 Modern Food Science and Technology, 2015, 卷号: 31, 期号: 3, 页码: 12-17 作者:  Zhang, Bai-Gang;  Peng, Xiao-Li;  Li, Guang-Hui;  Xu, Yun-Feng;  Xia, Xiao-Dong 收藏  |  浏览/下载：8/0  |  提交时间：2020/11/14 Cell death  Cell membranes  Cell proliferation  Cytology  Fluorescence  Fluorescence microscopy  Gene expression  Genes  Magnesium printing plates  Mitochondria  Polymerase chain reaction  Scanning electron microscopy  Toxic materials  Dose-dependent manner  Human embryonic kidney cells  Mitochondrial membrane potential  Mitochondrial pathways  Morphological changes  Patulin  Proliferation and apoptosis  Real-time fluorescent   The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis 期刊论文 NATURE COMMUNICATIONS, 2015 Shen, Chong; Rathore, Shailendra S.; Yu, Haijia; Gulbranson, Daniel R.; Hua, Rui; Zhang, Chen; Schoppa, Nathan E.; Shen, Jingshi 收藏  |  浏览/下载：2/0  |  提交时间：2017/12/03 INTRACELLULAR MEMBRANE-FUSION  SYNTAXIN N-PEPTIDE  NEUROTRANSMITTER RELEASE  SEC1/MUNC18 PROTEINS  VESICLE FUSION  DEPENDENT MANNER  STXBP1 MUTATIONS  BINDING MODE  SEC1 HOMOLOG  IN-VITRO   Shorter dinner-to-bed time is associated with gastric cardia adenocarcinoma risk partly in a reflux-dependent manner 会议论文 第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议 作者:  Qing-xu Song;  Jian-bo Wang;  Yi-bin Jia;  Chuan Wang;  Na-na Wang 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/31 time  Shorter dinner-to-bed time is associated with gastric cardia adenocarcinoma risk partly in a reflux-dependent manner   Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model 期刊论文 International Journal of Nanomedicine, 2013, 卷号: 8, 期号: 1, 页码: 3107-3118 作者:  Chen, Yan;  Yang, Lifang*;  Huang, Suping;  Li, Zhi;  Zhang, Lu 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 DNAzymes are synthetic  single-stranded  catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner  and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with potentially wide application  nanohydroxyapatite particles (nHAP) have attracted increasing attention as new candidates for nonviral vectors. In this study  we developed an nHAP-based delivery system and explored its cellular uptake mechanisms  intracellular localization  and biological effects. Absorption of arginine-modified nanohydroxyapatite particles (Arg-nHAP) and DZ1 (latent membrane protein 1 [LMP1]-targeted) reached nearly 100% efficiency under in vitro conditions. Using specific inhibitors  cellular uptake of the Arg-nHAP/DZ1 complex was shown to be mediated by the energy-dependent endocytosis pathway. Further  effective intracellular delivery and nuclear localization of the complex was confirmed by confocal microscopy. Biologically  the complex successfully downregulated the expression of LMP1 in nasopharyngeal carcinoma cells. In a mouse tumor xenograft model  the complex was shown to be delivered efficiently to tumor tissue  downregulating expression of LMP1 and suppressing tumor growth. These results suggest that Arg-nHAP may be an efficient vector for nucleic acid-based drugs with potential clinical application.   Four flavonoid glycosides from the pulps of Elaeagnus angustifolia and their antioxidant activities 会议论文 Nanjing, Jiangsu, China, September 14, 2013 - September 15, 2013 作者:  Wang, Ya;  Guo, Tao;  Li, Jia-Yin;  Zhou, Shang-Zhen;  Zhao, Ping 收藏  |  浏览/下载：7/0  |  提交时间：2020/11/15 Agents  Flavonoids  Information technology  Materials science  Oxygen  Phenols  Sugars  Anti-oxidant activities  Antioxidant capacity  Dose-dependent manner  Elaeagnus angustifolia  Flavonoid  Flavonoid glycosides  Structure activity relationships  Superoxide anions