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科研机构
山东大学 [11]
复旦大学上海医学院 [3]
中南大学 [1]
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期刊论文 [13]
会议论文 [1]
学位论文 [1]
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2019 [1]
2018 [2]
2017 [1]
2016 [3]
2015 [1]
2014 [2]
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Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 4, 页码: 430-437
作者:
Kang, Dongwei
;
Wang, Zhao
;
Chen, Meng
;
Feng, Da
;
Wu, Gaochan
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/11
DAPY
HIV-1
NNRTIs
solvent-exposed region I
thiophene[3
2-d]pyrimidine
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 9, 期号: 4, 页码: 370-375
作者:
Kang, Dongwei
;
Wang, Zhao
;
Zhang, Heng
;
Wu, Gaochan
;
Zhao, Tong
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/11
HIV-1
NNRTIs
DAPY
tolerant regions
drug design
The discovery of novel diarylpyri(mi) dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 2051-2060
作者:
Lu, Xueyi
;
Yang, Jiapei
;
Kang, Dongwei
;
Gao, Ping
;
Daelemans, Dirk
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HIV-1
HIV-2
NNRTIs
DAPY
Drug design
Entrance channel
Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 16, 页码: 4397-4406
作者:
Huang, Boshi
;
Wang, Xueshun
;
Liu, Xinhao
;
Chen, Zihui
;
Li, Wanzhuo
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
HIV-1 inhibitors
DAPY-IAS hybrids
Crystallographic overlays
Drug
design
SARs
Molecular modeling
Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 109, 页码: 294-304
作者:
Yang, Jiapei
;
Chen, Wenmin
;
Kang, Dongwei
;
Lu, Xueyi
;
Li, Xiao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
HIV-1
NNRTIs
DAPY
Molecular hybridization
Drug design
Entrance
channel
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 115, 页码: 53-62
作者:
Meng, Qing
;
Chen, Xuwang
;
Kang, Dongwei
;
Huang, Boshi
;
Li, Wenxin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/17
HIV-1 NNRTIs
DAPY derivatives
Dual structural conformations
Entrance
channel
SARs
基于靶点结构的新型DAPY类HIV-1 NNRTIs的设计、合成及活性研究
会议论文
中国化学会第30届学术年会-第二十八分会:化学生物学
作者:
李潇
;
展鹏
;
刘新泳
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/31
HIV-1
NNRTIs
DAPY
Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 97
作者:
Wan, Zheng-Yong
;
Yao, Jin
;
Tao, Yuan
;
Mao, Tian-Qi
;
Wang, Xin-Long
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Antiviral agent
Biological activity
DAPY
NNRTI
Piperidine
Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: Discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 85, 页码: 293-303
作者:
Wang, Liu
;
Tian, Ye
;
Chen, Wenmin
;
Liu, Hong
;
Zhan, Peng
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/17
DAPY
[1,2,4]Triazolo[1,5-a]pyrimidine
Bridgehead nitrogen heterocycle
anti-HIV activities
Structure-activity relationships
Molecular
modeling
Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 80, 页码: 112-121
作者:
Li, Xiao
;
Chen, Wenmin
;
Tian, Ye
;
Liu, Huiqing
;
Zhan, Peng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/23
HIV-1
HIV-2
DAPY
Anti-HIV activities
Structure-activity
relationships
Molecular modeling
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