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期刊论文 [24]
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Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
Metabolic disposition of the EGFR covalent inhibitor furmonertinib in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Meng, Jian
;
Zhang, Hua
;
Bao, Jing-jing
;
Chen, Zhen-dong
;
Liu, Xiao-yun
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2021/06/11
metabolism
mass balance
distribution
covalent binding
furmonertinib
Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins
期刊论文
DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 35, 期号: 5, 页码: 456-465
作者:
Liu, Xiaoyun
;
Feng, Dan
;
Zheng, Mingyue
;
Cui, Yongmei
;
Zhong, Dafang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/21
Covalent tyrosine kinase inhibitors
Covalent binding
Human serum albumin
Molecular docking
Quantitative calculations
Linear modeling
Species difference
metabolismanddispositionofpyrotinibinhealthymalevolunteerscovalentbindingwithhumanplasmaprotein
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 7, 页码: 980
作者:
Meng Jian
;
Liu Xiaoyun
;
Ma Sheng
;
Zhang Hua
;
Yu Songda
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
pyrotinib
EGFR/HER2 dual tyrosine kinase inhibitor
breast cancer
drug metabolism
drug disposition
human plasma
covalent binding
Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity
期刊论文
JOURNAL OF FOOD AND DRUG ANALYSIS, 2018, 卷号: 26, 期号: 3, 页码: 965-972
作者:
Ma, Jiang
;
Xia, Qingsu
;
Fu, Peter P.
;
Lin, Ge
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Pyrrolizidine alkaloids
Pyrrole-protein adducts
Covalent binding
Target protein
Mechanism-based biomarker
Clinical diagnosis
Ferric Oxide-reduced Graphene Oxide Composite Material: Synthesis Based on Covalent Binding and Its Lithium-storage Property
期刊论文
JOURNAL OF INORGANIC MATERIALS, 2018, 卷号: Vol.33 No.7, 页码: 741-748
作者:
Qin, Shi-Lin
;
Li, Ji-Cheng
;
Li, Zhao-Hui
;
Hu, Zhong-Liang
;
Ding, Yan-Huai
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/26
ferroferric oxide
graphene oxide
covalent binding interaction
lithium-ion batteries
Transformation of halobenzoquinones with the presence of amino acids in water: Products, pathways and toxicity
期刊论文
WATER RESEARCH, 2017, 卷号: 122, 页码: 299-307
作者:
Du, Penghui
;
Zhao, He
;
Cao, Hongbin
;
Huang, Ching-Hua
;
Liu, Wen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2017/11/27
Disinfection Byproducts (Dbps)
Halobenzoquinone (Hbq)
Amino Acids
Nucleophilic Reaction
Covalent Binding
Toxicity
Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 89, 期号: 5, 页码: 655-662
作者:
Wu, Sijin
;
Zhang, Keren
;
Qin, Hongqiang
;
Niu, Mingshan
;
Zhao, Weijie
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/10/29
Caffeic Acid Phenethyl Ester
Covalent Binding
Nuclear Export
Xpo1
Crm1
Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 89, 页码: 655-662
作者:
Wu, Sijin
;
Zhang, Keren
;
Qin, Hongqiang
;
Niu, Mingshan
;
Zhao, Weijie
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/02
caffeic acid phenethyl ester
covalent binding
nuclear export
XPO1
CRM1
Molecular docking for drug discovery and development: a widely used approach but far from perfect
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2016, 卷号: 8, 期号: 14
作者:
Wang, Guimin
;
Zhu, Weiliang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
covalent binding
free energy
molecular docking
scoring function
solvent molecule
structural flexibility
thermodynamics and kinetics
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