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Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan. 期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:  Yiqiao Gao;  Wei Li;  Jiaqing Chen;  Xu Wang;  Yingtong Lv
收藏  |  浏览/下载:55/0  |  提交时间:2019/12/17
AUC-ROC,  area  under  receiver  operating  characteristic  BHB,  β-hydroxybutyric  acid  Biomarkers  C,  control  group  CA,  cholic  acid  CPT-11,  irinotecan  Complicating  toxicity  DBIL,  direct  bilirubin  DCA,  deoxycholic  acid  Diarrhea  FDR,  false  discovery  rate  GCA,  glycocholic  acid  Gastrointestinal  toxicity  IBIL,  indirect  bilirubin  IT-TOF/MS,  ion  trap/time-offlight  hybrid  mass  spectrometry  Individual  differences  Irinotecan  Lys,  lysine  MSTFA,  N-methyl-N-trifluoroacetamide  Metabolomics  NS,  non-sensitive  group  NSgt,  non-sensitive  for  gastrointestinal  toxicity  NSmt,  non-sensitive  for  myelosuppression  toxicity  OPLS-DA,  orthogonal  partial  least-squares-discriminant  analysis  PCA,  principal  component  analysis  PLS-DA,  partial  least-squares-discriminant  analysis  Phe,  phenylalanine  Prediction  QC,  quality  control  RSD,  relative  standard  deviation  S,  sensitive  group  Sgt,  sensitive  for  gastrointestinal  toxicity  Smt,  sensitive  for  myelosuppression  toxicity  T,  CPT-11  treated  group  Trp,  tryptophan  UFLC,  ultrafast  liquid  chromatography  VIP,  variable  importance  in  the  projection  pFDR,  false-discovery-rate-adjusted  P  value  
Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency 期刊论文
2019, 卷号: 14, 页码: 301-315
作者:  Li, Ying;  Yang, Dandan;  Wang, Yian;  Li, Zhan;  Zhu, Chunyan
收藏  |  浏览/下载:50/0  |  提交时间:2020/01/03
Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes 期刊论文
2017, 卷号: 12, 页码: 1673-1684
作者:  Li, Ying;  Zhu, Chunyan
收藏  |  浏览/下载:8/0  |  提交时间:2020/01/03
Novel DSPE-PEG-Cholic Acid-Modified Liposomes with Hepatic Targeting Properties Improve the Anti-Tumor Efficacy of Oral Doxorubicin Hydrochloride for Liver Tumor-Bearing Mice 期刊论文
2017, 卷号: 13, 期号: 6, 页码: 727-736
作者:  Li, Ying;  Yang, Dandan;  Zhang, Yun;  Zhu, Chunyan
收藏  |  浏览/下载:7/0  |  提交时间:2020/01/03
Effective Enhancement of Hypoglycemic Effect of Insulin by Liver Targeted Nanoparticles Containing Cholic Acid-Modified Chitosan Derivative 期刊论文
MOLECULAR PHARMACEUTICS, 2016, 卷号: 13, 期号: 7
作者:  Zhang, Zhe;  Cai, Huanxin;  Liu, Zhijia;  Yao, Ping
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/05
Fluorescent molecularly imprinted polymers based on 1,8-naphthalimide derivatives for efficiently recognition of cholic acid 期刊论文
Materials Science and Engineering C, 2016, 卷号: 58, 页码: 558-567
作者:  Xu, Zhifeng*;  Deng, Peihong;  Tang, Siping;  Li, Junhua
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/24
Synthesis and Antitumor Activity of Cholic acid-α-aminophosphonate Derivatives 会议论文
河南省化学会2016年学术年会, 2016-08-01
作者:  Shenshen Guo[1];  Jin Chen[2];  Cuimeng Huo[3];  Bencai Dai[4];  Xiaoli Liu[5]
收藏  |  浏览/下载:7/0  |  提交时间:2019/12/23
A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine 期刊论文
分子生物系统, 2015
Gu, Shenghua; Cao, Bei; Sun, Runbin; Tang, Yueqing; Paletta, Janice L.; Wu, Xiao-Lei; Liu, Linsheng; Zha, Weibin; Zhao, Chunyan; Li, Yan; Radlon, Jason M.; Hylemon, Phillip B.; Zhou, Huiping; Aa, Jiye; Wang, Guangji
收藏  |  浏览/下载:9/0  |  提交时间:2015/11/10
Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography-tandem mass spectrometry. 期刊论文
Acta pharmaceutica Sinica. B, 2014, 卷号: 4, 期号: 5
作者:  Zhang Zhongliang;  ;  Li Qiang;  ;  Li Qiufen
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/05
An in vitro metabolic system of gut flora and the metabolism of ginsenoside Rg3 and cholic acid 期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2014, 卷号: 39, 期号: 2
作者:  Zhao, Chunyan;  Sun, Runbin;  Cao, Bei;  Gu, Shenghua;  Zhao, Jieyu
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/05


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