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清华大学 [4]
北京大学 [4]
四川大学 [3]
复旦大学上海医学院 [3]
中国医学科学院 北京... [3]
上海中医药大学 [2]
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期刊论文 [24]
会议论文 [2]
其他 [1]
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2019 [2]
2017 [2]
2016 [3]
2015 [1]
2014 [4]
2012 [1]
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Chemistry,... [1]
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Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
Co-delivery doxorubicin and silybin for anti-hepatoma via enhanced oral hepatic-targeted efficiency
期刊论文
2019, 卷号: 14, 页码: 301-315
作者:
Li, Ying
;
Yang, Dandan
;
Wang, Yian
;
Li, Zhan
;
Zhu, Chunyan
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/01/03
doxorubicin
silybin
hepatic targeting via oral administration
cholic acid transporter
anti-hepatoma
biodistribution in vivo
Mechanism of hepatic targeting via oral administration of DSPE-PEG-cholic acid-modified nanoliposomes
期刊论文
2017, 卷号: 12, 页码: 1673-1684
作者:
Li, Ying
;
Zhu, Chunyan
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
DSPE-PEG-cholic acid
nanoliposomes
hepatic targeting via oral administration
mechanism
FRET
Novel DSPE-PEG-Cholic Acid-Modified Liposomes with Hepatic Targeting Properties Improve the Anti-Tumor Efficacy of Oral Doxorubicin Hydrochloride for Liver Tumor-Bearing Mice
期刊论文
2017, 卷号: 13, 期号: 6, 页码: 727-736
作者:
Li, Ying
;
Yang, Dandan
;
Zhang, Yun
;
Zhu, Chunyan
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Hepatic Targeting Drug Delivery via Oral Administration
DSPE-PEG-Cholic Acid
Functional Liposomes
Orthotopic Liver Tumor Mice Model
Doxorubicin Hydrochloride
Effective Enhancement of Hypoglycemic Effect of Insulin by Liver Targeted Nanoparticles Containing Cholic Acid-Modified Chitosan Derivative
期刊论文
MOLECULAR PHARMACEUTICS, 2016, 卷号: 13, 期号: 7
作者:
Zhang, Zhe
;
Cai, Huanxin
;
Liu, Zhijia
;
Yao, Ping
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
chitosan
cholic acid
diabetes mellitus
insulin
liver target
nanoparticle
Fluorescent molecularly imprinted polymers based on 1,8-naphthalimide derivatives for efficiently recognition of cholic acid
期刊论文
Materials Science and Engineering C, 2016, 卷号: 58, 页码: 558-567
作者:
Xu, Zhifeng*
;
Deng, Peihong
;
Tang, Siping
;
Li, Junhua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/24
1,8-naphthalimide
Cholic acid
Fluorescence intensity
Molecular imprinting
Molecular recognition
Synthesis and Antitumor Activity of Cholic acid-α-aminophosphonate Derivatives
会议论文
河南省化学会2016年学术年会, 2016-08-01
作者:
Shenshen Guo[1]
;
Jin Chen[2]
;
Cuimeng Huo[3]
;
Bencai Dai[4]
;
Xiaoli Liu[5]
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/23
cholic acid
α-aminophosphonates
antitumor activity
A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine
期刊论文
分子生物系统, 2015
Gu, Shenghua
;
Cao, Bei
;
Sun, Runbin
;
Tang, Yueqing
;
Paletta, Janice L.
;
Wu, Xiao-Lei
;
Liu, Linsheng
;
Zha, Weibin
;
Zhao, Chunyan
;
Li, Yan
;
Radlon, Jason M.
;
Hylemon, Phillip B.
;
Zhou, Huiping
;
Aa, Jiye
;
Wang, Guangji
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2015/11/10
SALT HYDROLASE ACTIVITY
GUT MICROBIOTA
CLOSTRIDIUM-SCINDENS
MASS-SPECTROMETRY
CHOLIC-ACID
MOUSE MODEL
BILE
LIVER
MICE
METABOLITES
Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography-tandem mass spectrometry.
期刊论文
Acta pharmaceutica Sinica. B, 2014, 卷号: 4, 期号: 5
作者:
Zhang Zhongliang
;
;
Li Qiang
;
;
Li Qiufen
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
5-O-M
5-O-methylvisammioside
AST-III
astragaloside III
AST-IV
astragaloside IV
Active components
BER
berberine
CA
cholic acid
CCS
calycosin
CCSG
calycosin-7-O-β-d-glucoside
CE
collision energy
CSR
cervical spondylosis radiculopathy
DAI
daidzein
FAN
fangchinoline
FOR
formonone...
An in vitro metabolic system of gut flora and the metabolism of ginsenoside Rg3 and cholic acid
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2014, 卷号: 39, 期号: 2
作者:
Zhao, Chunyan
;
Sun, Runbin
;
Cao, Bei
;
Gu, Shenghua
;
Zhao, Jieyu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
In vitro
Gut flora
Metabolism
Ginsenoside Rg3
Cholic acid
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