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A Nestin-Cyclin-Dependent Kinase 5-Dynamin-Related Protein 1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift 期刊论文
STEM CELLS, 2018, 卷号: 36, 页码: 589-601
作者:  Wang, Jiancheng;  Huang, Yinong;  Cai, Jianye;  Ke, Qiong;  Xiao, Jiaqi
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway 期刊论文
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, 卷号: 51, 期号: 6, 页码: 2604-2615
作者:  Shu Yang[1];  Xiang Min[2];  Zhang Pei[3];  Qi Guangjian[4];  He Feng[5]
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/24
细胞周期素依赖蛋白激酶5促进肝细胞癌的侵袭与转移 学位论文
2017, 2016
赵文兴
收藏  |  浏览/下载:5/0  |  提交时间:2017/06/20
Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017, 卷号: 36
作者:  Wang, Yitao;  Qin, Xian;  Guo, Tao;  Liu, Pengpeng;  Wu, Ping
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/05
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway 期刊论文
2017, 卷号: 492, 期号: 3, 页码: 447-452
作者:  Zhou, Xiaoshu;  Gu, Runxia;  Han, Xiaoming;  Wu, Gang;  Liu, Junli
收藏  |  浏览/下载:4/0  |  提交时间:2020/01/03
Regulation of thin recipe of Buyang Huanwudecoction on Cdk5 expression of rats after cerebral ischemia 期刊论文
Chinese Pharmacological Bulletin, 2017, 卷号: Vol.33 No.8, 页码: 1176-1181
作者:  Liu Fang;  Wang Yuhong;  Shao Le;  Xia Xiangyi;  She Yan
收藏  |  浏览/下载:2/0  |  提交时间:2019/12/31
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载:17/0  |  提交时间:2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载:19/0  |  提交时间:2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells 期刊论文
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, 卷号: 23, 期号: 13, 页码: 1555-1565
作者:  Chen, Xin;  Wu, Qiu-Shuang;  Meng, Fan-Cheng;  Tang, Zheng-Hai;  Chen, Xiuping
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/27
Panacis Japonici Rhizoma  Chikusetsusaponin IVa methyl ester  Ovarian cancer  Cell cycle arrest  Apoptosis  Metastasis  Bcl-2  B-cell lymphoma 2  CC  column chromatography  CDK  cyclin-dependent kinase  DMEM  Dulbecco's modified Eagle's medium  DMSO  dimethyl sulfoxide  FBS  fetal bovine serum  GAPDH  Glyceraldehyde 3-phosphate dehydrogenase  Hoechst 33342  2′-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2,5′-bi-1H-benzimidazole trihydrochloride trihydrate  JC-1  5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide  MMP  matrix metalloproteinase  MTT  3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide  PARP  Poly (ADP-ribose) polymerase  PBS  phosphate-buffered saline  PI  ropidium iodide  PJR  Panacis Japonici Rhizoma  SD  standard deviation  


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