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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Deficiency of nitrogen but not phosphorus triggers the life cycle transition of the dinoflagellate Scrippsiella acuminata from vegetative growth to resting cyst formation
期刊论文
HARMFUL ALGAE, 2022, 卷号: 118, 页码: 10
作者:
Tang, Ying Zhong
;
Deng, Yunyan
;
Yue, Caixia
;
Chai, Zhaoyang
;
Shang, Lixia
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  |  
浏览/下载:19/0
  |  
提交时间:2023/01/04
Resting cyst
Harmful algal blooms (HABs)
Cell cycle
CyclinB
CDK1
Scrippsiella acuminata
Role of FUS-CHOP in Myxoid Liposarcoma via miR-486/CDK4 Axis
期刊论文
BIOCHEMICAL GENETICS, 2021
作者:
Wu, Hao
;
Xia, Liming
;
Xu, Haichao
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  |  
浏览/下载:38/0
  |  
提交时间:2022/01/10
FUS-CHOP
Myxoid liposarcoma
Apoptosis
miR-486
CDK4 axis
Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhibition
期刊论文
CHINESE CHEMICAL LETTERS, 2021, 卷号: 32, 期号: 6, 页码: 1929-1936
作者:
Gao, Jing
;
Zhang, Hanwu
;
Zhou, Fengqi
;
Hou, Bo
;
Chen, Meiwan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
Cancer immunotherapy
siRNA delivery
Acid-activatible micelleplex
CDK4
6 inhibitor
PD-L1 knockdown
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12
作者:
Lin, Tingting
;
Li, Jiacheng
;
Liu, Liping
;
Li, Yuanqing
;
Jiang, Hualiang
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  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
CDK2 inhibitor
Selectivity
Anti-proliferative potency
Phospho-regulation and function of ULK1-ATG13 during the cell cycle
期刊论文
AUTOPHAGY, 2021
作者:
Li, Zhiyuan
;
Zhang, Xin
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  |  
浏览/下载:21/0
  |  
提交时间:2021/04/26
ULK1
ATG13
CDK1
autophagy
mitosis
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 11
作者:
Qiu, Xiaqiu
;
Li, Yuanqing
;
Yu, Bin
;
Ren, Jie
;
Huang, Huidan
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  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
CDK9
Antitumor
PROTAC
AML
Degrader
Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 卷号: 8
作者:
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  |  
浏览/下载:19/0
  |  
提交时间:2020/10/21
CDK8
transcriptional regulation
e2f1
apaf1
radiotherapy
apoptosis
Arsenic trioxide (ATO) induced degradation of Cyclin D1 sensitized PD-1/PD-L1 checkpoint inhibitor in oral and esophageal squamous cell carcinoma
期刊论文
JOURNAL OF CANCER, 2020, 卷号: 11
作者:
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  |  
浏览/下载:19/0
  |  
提交时间:2020/11/30
esophageal squamous cell carcinoma
oral squamous cell carcinoma
arsenic trioxide
cyclin D1
PD-L1
CDK4/6
Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 782-801
作者:
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Wogonin
CDK9
AML
Flavonoid
Antitumor
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