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科研机构
上海药物研究所 [5]
西安交通大学 [2]
山东大学 [1]
复旦大学上海医学院 [1]
昆明动物研究所 [1]
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期刊论文 [10]
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2017 [1]
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2008 [2]
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Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors
期刊论文
高等学校化学研究, 2017, 卷号: 33, 期号: 1, 页码: 49-60
作者:
Cai Wenqing
;
Liu Wei
;
Xie Yafei
;
Wu Jingwei
;
Liu Yuqiang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/12
URAT1 inhibitor
Structure-activity relationship
Drug discovery
Lesinurad
Tetrazole
Bioisostere
Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 卷号: 64, 期号: 4, 页码: 326-339
作者:
Chen, Zhixiang
;
Ning, Mengmeng
;
Zou, Qingan
;
Cao, Hua
;
Ye, Yangliang
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Takeda G-protein-coupled receptor 5 agonist
bioisostere
microsomal clearance
structure-activity relationship
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 14, 页码: 3670-3683
作者:
Zhi, Ying
;
Gao, Li-Xin
;
Jin, Yi
;
Tang, Chun-Lan
;
Li, Jing-Ya
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B inhibitor
4-Quinolone-3-carboxylic acid
Bidentate ligand
Bioisostere
Insulin receptor signaling
Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 75, 期号: [db:dc_citation_issue], 页码: 96-105
作者:
Shao, Teng
;
Wang, Juan
;
Chen, Jian-Gang
;
Wang, Xiao-Meng
;
Li, Huan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Quinazoline
Bioisostere
Anticancer effect
Antiproliferative activity
PI3K inhibitor
Benzamide
Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: [db:dc_citation_issue], 页码: 3739-3748
作者:
Li, Huan
;
Wang, Xiao-Meng
;
Wang, Juan
;
Shao, Teng
;
Li, Yi-Ping
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
Bioisostere
Anticancer effect
Benzamide
Benzothiazole
Synthesis
Design, synthesis and SAR of piperidyl-oxadiazoles as 11 beta-hydroxysteroid dehydrogenase 1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 62, 页码: 1-10
作者:
Xia, Guangxin
;
You, Xiaodi
;
Liu, Lin
;
Liu, Haiyan
;
Wang, Jianfa
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
11 beta-HSD1 inhibitor
Oxadiazole
Bioisostere
SAR
Docking
Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 7, 页码: 2219-2223
作者:
Zhang, Hu-Shan
;
Feng, Dong-Zhi
;
Chen, Li
;
Long, Ya-Qiu
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
CCR5 antagonist
HIV-1 entry inhibitor
Functionality inversion
Bioisostere
Butanamide
Tropane
2-Methyl-3H-imidazo[4,5-b]pyridine
3H-[1,2,3]Triazolo[4,5-b]pyridine
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:
Zeng, Li-Fan
;
Zhang, Hu-Shan
;
Wang, Yun-Hua
;
Sanchez, Tino
;
Zheng, Yong-Tang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
HIV-1 integrase inhibitor
bioisostere
heteroaromatic carboxylic acid
isoxazole
isothiazole
1H-pyrazole
bioavailability
antiviral effect
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 16, 页码: 4521-4524
作者:
Zeng LF
;
Zhang HS
;
Wang YH
;
Sanchez T
;
Zheng YT
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2010/08/24
HIV-1 integrase inhibitor
bioisostere
heteroaromatic carboxylic acid
isoxazole
isothiazole
1H-pyrazole
bioavailability
antiviral effect
Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 卷号: 17, 期号: 15
作者:
Wang, Yang
;
Huang, Shao-Xu
;
Xia, Peng
;
Xia, Yi
;
Yang, Zheng-Yu
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/19
anti-HIV activity
DCK
bioisostere
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