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科研机构
北京大学 [4]
大连理工大学 [4]
山东大学 [3]
南华大学 [2]
清华大学 [2]
上海药物研究所 [2]
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期刊论文 [27]
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2019 [1]
2018 [3]
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Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 13, 页码: 2771-2783
作者:
Chen, Chen
;
Nie, Yiming
;
Xu, Guangsen
;
Yang, Xinying
;
Fang, Hao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/11
Apoptosis
Anticancer
Bcl-2/Mcl-1 dual inhibitor
Indomethacin
derivatives
Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 97, 页码: 213-224
作者:
Yu, Shuo
;
Gong, Lian-sheng*
;
Li, Nian-feng
;
Pan, Yi-feng
;
Zhang, Lun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/03
MTT
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide
GG
Galangin
DDP
cisplatin
STAT3
signal transducers and activation of transcription
LC
Lung cancer
MDR
multidrug resistance
NSCL
Cnon-small cell lung cancer
Bcl-2
B-cell leukemia/lymphoma 2
Bax
bcl-2-like protein
TRAIL
TNF-related apoptosis-inducing ligand
NF-κB
nuclear factor kappa-light-chain-enhancer of activated B cells
IκBα
inhibitor of NF-κBα
Cyto-c
cytochrome c
Lung cancer
Galangin
Cisplatin
p-STAT3/p65
Bcl-2
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid leukemia: a case report
期刊论文
FRONTIERS OF MEDICINE, 2018, 卷号: 12
-
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/10/26
BCL-2 INHIBITOR
MIDOSTAURIN
CLASSIFICATION
DECITABINE
MECHANISMS
MUTATIONS
TARGETS
IDH
BTK
venetoclax
cytarabine
AML
leukemia
Recent advances in gossypol derivatives and analogs: a chemistry and biology view
期刊论文
FUTURE MEDICINAL CHEMISTRY, 2017, 卷号: 9, 期号: 11
作者:
Lu, Yuzhi
;
Li, Jun
;
Dong, Chun-E
;
Huang, Jian
;
Zhou, Hai-Bing
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
antiapoptotic
antitumor
Bcl-2 inhibitor
gossypol
gossypol derivatives
natural product chemistry
polyphenols
scaffold hopping
structure-activity relationship
synthetic chemistry
Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells
期刊论文
ONCOLOGY REPORTS, 2016, 卷号: 36, 期号: 6
作者:
Li, Xiaoning
;
Kang, Yongwei
;
Jiao, Bingxuan
;
Xia, Meihui
;
Wu, Yao
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
Bcl-2 inhibitor
ER membrane reorganization
unfolded protein response
autophagy
Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance
期刊论文
Oncotarget, 2016, 卷号: 7, 期号: 47
作者:
Wu, Yi-Xin
;
Yang, Jia-Hua
;
Saitsu, Hirotomo
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
bortezomib resistant
proteasome inhibitor
hepatocellular carcinoma cell
BCL2
apoptosis
Bortezomib-resistance is associated with increased levels of proteasome subunits and apoptosis-avoidance
期刊论文
Oncotarget, 2016, 卷号: 7, 页码: 77622-77634
作者:
Wu Yi-Xin[1]
;
Yang Jia-Hua[2]
;
Saitsu Hirotomo[3]
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/04/26
BCL2
apoptosis
bortezomib resistant
hepatocellular carcinoma cell
proteasome inhibitor
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y
期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:
Ma, Yun*
;
Tian, Shuai
;
He, Shuya*
;
Chen, Qiong
;
Wang, Zongbao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/27
mRNA
messenger ribonucleic acid
miRNA
micro ribonucleic acid
TNF-α
tumor necrosis factor-alpha
SH-SY5Y
cells SH-SY5Y neuroblastoma cells
Ago2
Argonaute 2
USP32
ubiquitin specific peptidase 32
RAB18
member RAS oncogene family
Dusp6
dual specificity phosphatase 6
Cdkn1a
cyclin-dependent kinase inhibitor 1A
Bcl-2
B-cell lymphoma-2
FMRP
fragile X mental retardation protein
FXR1P
fragile X-related 1 protein
FXR2P
fragile X-related 2 protein
3′UTR
3′untranslated regions
CDS
coding sequence
FACS
fluorescence activated cell sorter
PMSF
phenylmethanesulfonyl fluoride
SDS-PAGE
sodium dodecyl sulfate-polyacrylamide gel electrophoresis
ANOVA
analysis of variance
SD
standard deviation
PCR
polymerase chain reaction
miR-19b
FXR1
RAB18
USP32
Dusp6
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