Apoptosis  Anticancer  Bcl-2/Mcl-1 dual inhibitor  Indomethacin  derivatives  

ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  

antiapoptotic  antitumor  Bcl-2 inhibitor  gossypol  gossypol derivatives  natural product chemistry  polyphenols  scaffold hopping  structure-activity relationship  synthetic chemistry  

bortezomib resistant  proteasome inhibitor  hepatocellular carcinoma cell  BCL2  apoptosis  

mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6