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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Differential Reprogramming of Defense Network in Capsicum annum L. Plants Against Colletotrichum truncatum Infection by Phyllospheric and Rhizospheric Trichoderma Strains
期刊论文
JOURNAL OF PLANT GROWTH REGULATION, 2020, 卷号: 39, 期号: 2, 页码: 751-763
作者:
Saxena, Amrita
;
Mishra, Sandhya
;
Ray, Shatrupa
;
Raghuwanshi, Richa
;
Singh, Harikesh Bahadur
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/06/24
Capsicum annuum L
Colletotrichum truncatum
Induced systemic response (ISR)
Phyllosphere
Trichoderma spp
Systemic acquired resistance (SAR)
Molecular insight into the T798M gatekeeper mutation-caused acquired resistance to tyrosine kinase inhibitors in ErbB2-positive breast cancer
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 78
作者:
Lu, Ji
;
Zhou, Kun
;
Yin, Xiaoxing
;
Xu, Han
;
Ma, Baojin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Epidermal growth factor receptor 2
Gatekeeper mutation
Tyrosine kinase inhibitor
Acquired resistance
Breast cancer
Novel-smoothened inhibitors for therapeutic targeting of naive and drug-resistant hedgehog pathway-driven cancers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 2
作者:
Li, Qing-rou
;
Zhao, Hui
;
Zhang, Xue-sai
;
Lang, Henk
;
Yu, Ker
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
hedgehog
smoothened inhibitor
paracrine
acquired drug resistance
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: Vol.40 No.2, 页码: 268-278
作者:
Gao, Ming-zhao
;
Wang, Hong-bin
;
Chen, Xiang-ling
;
Cao, Wen-ting
;
Fu, Li
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/13
BRAF-mutant melanoma
MAPK pathway inhibitors
acquired resistance
P70S6K
RSK
rpS6
G(1)/G(0) phase arrest
mTOR inhibitor
Local Thermal Ablation with Continuous EGFR Tyrosine Kinase Inhibitors for EGFR-Mutant Non-small Cell Lung Cancers that Developed Extra-Central Nervous System (CNS) Oligoprogressive Disease
期刊论文
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2019, 卷号: 42, 期号: 5, 页码: 693-699
作者:
Ni, Yang
;
Liu, Baodong
;
Ye, Xin
;
Fan, Weijun
;
Bi, Jingwang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Thermal ablation
Microwave ablation
Radiofrequency ablation
EGFR-TKI
acquired resistance
Oligoprogression
Prevalence of HIV-1 Drug Resistance among Patients with Antiretroviral Therapy Failure in Sichuan, China, 2010-2016.
期刊论文
The Tohoku journal of experimental medicine, 2019, 卷号: Vol.247 No.1, 页码: 1-12
作者:
Ke Dong
;
Li Ye
;
Yun Leng
;
Shu Liang
;
Liao Feng
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/12/13
AIDS
HIV
Sichuan
acquired
drug
resistance
antiretroviral
therapy
aberrantmodulationofribosomalproteins6phosphorylationconfersacquiredresistancetomapkpathwayinhibitorsinbrafmutantmelanoma
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 268
作者:
Mingzhao Gao
;
Hongbin Wang
;
Xiangling Chen
;
Wenting Cao
;
Li Fu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
BRAF-mutant
melanoma
MAPK
pathway
inhibitors
acquired
resistance
P70S6K
RSK
rpS6
G1/G0
phase
arrest
mTOR
inhibitor
Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 3, 页码: 821-831
作者:
Wang, Yu-Ting
;
Yuan, Bo
;
Chen, Hua-Dong
;
Xu, Lin
;
Tian, Yu-Nan
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/01/08
53BP1
acquired resistance
phosphatase and tensin homolog deficiency
poly(ADP-ribose) polymerase inhibitors
SAMHD1
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