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北京大学 [8]
上海药物研究所 [8]
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山东大学 [2]
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期刊论文 [29]
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Correlation of LOX-5 and COX-2 expression with inflammatory pathology and clinical features of adenomyosis
期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 19, 期号: 1
作者:
Chen, Li
;
Li, Caixia
;
Chen, Rong
;
Jiang, Caixia
;
Cheng, Zhongping
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/05
lipoxygenase-5
cyclooxygenase 2
adenomyosis
inflammatory pathology
menstruation
dysmenorrhea
Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE mice and lipopolysaccharide-stimulated RAW264.7 macrophages
期刊论文
Atherosclerosis, 2019
作者:
Yimin Pang
;
Lu Gan
;
Xianzhe Wang
;
Qi Su
;
Cong Liang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/17
Atherosclerosis
COX-2-selective inhibitors
Cyclooxygenase-2
5-Lipoxygenase
Leukotrienes
ApoE-/- mice
RAW264.7 macrophages
MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5
期刊论文
JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 卷号: 119, 期号: 2, 页码: 1755-1766
作者:
Wang, Dongxia
;
Li, Yuechun
;
Zhang, Chun
;
Li, Xianming
;
Yu, Jinming
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
5-lipoxygenase (ALOX5) (5-LO)
cell proliferation
colorectal cancer
(CRC)
cyclooxygenase-2 (COX-2)
miR-216a-3p
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase
期刊论文
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 1, 页码: 32-45
作者:
Zhou, Yu
;
Liu, Jun
;
Zheng, Mingyue
;
Zheng, Shuli
;
Jiang, Chunyi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
5-Lipoxygenase
5-LOX inhibitors
Pyrazole derivatives
Leukotrienes-related diseases
In vivo
Benzo-fuse heterocyle
Ischemic incults
Brain inflammation
structuraloptimizationandbiologicalevaluationofl5disubstitutedpyrazole3carboxaminesaspotentinhibitorsofhuman5lipoxygenase
期刊论文
actapharmaceuticasinicab, 2016, 卷号: 6, 期号: 1, 页码: 32
作者:
Zhou Yu
;
Liu Jun
;
Zheng Mingyue
;
Zheng Shuli
;
Jiang Chunyi
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
5-Lipoxygenase
5-LOX inhibitors
Pyrazole derivatives
Leukotrienes-related diseases
In vivo
Benzo-fused heterocycle
Ischemic incults
Brain inflammation
Structural optimization and biological evaluation of l,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase
期刊论文
Acta Pharmaceutica Sinica B, 2016, 卷号: 6, 期号: 1, 页码: 32
作者:
Zhou Yu
;
Liu Jun
;
Zheng Mingyue
;
Zheng Shuli
;
Jiang Chunyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
5-Lipoxygenase
5-LOX inhibitors
Pyrazole derivatives
Leukotrienes-related diseases
In vivo
Benzo-fused heterocycle
Ischemic incults
Brain inflammation
Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation
期刊论文
ACCOUNTS OF CHEMICAL RESEARCH, 2015
Meng, Hu
;
Liu, Ying
;
Lai, Luhua
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2017/12/03
PROSTAGLANDIN E-2 SYNTHASE-1
TRADITIONAL CHINESE MEDICINE
LEUKOTRIENE A(4) HYDROLASE
DUAL INHIBITORS
DRUG DESIGN
LTA(4) HYDROLASE
5-LIPOXYGENASE
DISCOVERY
DERIVATIVES
CYCLOOXYGENASE-2
Benzo[d] isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E-2 synthase-1
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 12, 页码: 2764-2767
作者:
Shang, Erchang
;
Wu, Yiran
;
Liu, Pei
;
Liu, Ying
;
Zhu, Wei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/04/09
5-lipoxygenase
Microsomal Prostaglandin E-2 Synthase
Dual Functional Inhibitor
Benzo[d] Isothiazole 1
1-dioxide
Identification of 1, 4-Dihydrothieno[3 ', 2 ':5, 6] thiopyrano [4, 3-c]pyrazole Derivatives as Human 5-Lipo-oxygenase Inhibitors
期刊论文
chemical biology drug design, 2014
Hu, Jianshu
;
Zhu, Wei
;
Meng, Hu
;
Liu, Ying
;
Wang, Xin
;
Hu, Chun
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/10
bioassay
cross-reactivity
human 5-lipo-oxygenase inhibitors
molecular docking
synthesis
LIPID MEDIATORS
5-LIPOXYGENASE
INFLAMMATION
LIGANDS
Benzo[d] isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E-2 synthase-1
期刊论文
生物有机化学与医药化学通讯, 2014
Shang, Erchang
;
Wu, Yiran
;
Liu, Pei
;
Liu, Ying
;
Zhu, Wei
;
Deng, Xiaobing
;
He, Chong
;
He, Shan
;
Li, Cong
;
Lai, Luhua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2015/11/10
Benzo[d] isothiazole 1,1-dioxide
5-Lipoxygenase
Microsomal prostaglandin E-2 synthase
Dual functional inhibitor
ANTIINFLAMMATORY DRUGS
MPGES-1
BIOLOGY
TARGET
5-LOX
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