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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
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浏览/下载:137/0
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提交时间:2019/06/28
Evolution of the electrochemical interface in sodium ion batteries with ether electrolytes
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 725
作者:
Li, Kaikai[1]
;
Zhang, Jun[2]
;
Lin, Dongmei[3]
;
Wang, Da-Wei[4]
;
Li, Baohua[5]
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浏览/下载:69/0
  |  
提交时间:2019/04/22
Switching to anastrozole plus goserelin vs continued tamoxifen for adjuvant therapy of premenopausal early-stage breast cancer: preliminary results from a randomized trial
期刊论文
Cancer management and research, 2019, 卷号: 11, 页码: 299-307
作者:
Li Jian-Wei[1]
;
Liu Guang-Yu[2]
;
Ji Ya-Jie[3]
;
Yan Xia[4]
;
Pang Da[5]
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浏览/下载:52/0
  |  
提交时间:2019/04/22
GnRH analogs
adjuvant therapy
anastrozole
aromatase inhibitors
breast cancer
tamoxifen
Non-proportionally multiaxial fatigue behavior of A319 casting alloy: effects of strontium addition and hot isostatic pressing
期刊论文
MATERIALS RESEARCH EXPRESS, 2019, 卷号: 6
作者:
Zhang Chen[1]
;
Liu Xiaoshan[2]
;
He Guoqiu[3]
;
Weng Zhenzhen[4]
;
Dai Liquan[5]
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浏览/下载:24/0
  |  
提交时间:2019/04/22
multiaxial fatigue
A319 alloy
Sr modification
HIP
fracture
Dose-response relationship between thyroid stimulating hormone and hypertension risk in euthyroid individuals
期刊论文
Journal of hypertension, 2019, 卷号: 37, 页码: 144-153
作者:
He Weiwei[1]
;
Li Sheli[2]
;
Wang Bin[3]
;
Mu Kaida[4]
;
Shao Xiaoqing[5]
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  |  
浏览/下载:36/0
  |  
提交时间:2019/04/22
Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis
期刊论文
EBioMedicine, 2019, 卷号: 41, 页码: 538-555
作者:
He Xiaojuan[1]
;
Liu Jin[2]
;
Liang Chao[3]
;
Badshah Shaikh Atik[4]
;
Zheng Kang[5]
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  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
Bone formation
Inflammation
Osteoblast
PLEKHO1
Rheumatoid arthritis
Author Correction: Evolution of the electrochemical interface in sodium ion batteries with ether electrolytes
期刊论文
Nature communications, 2019, 卷号: 10, 页码: 1248
作者:
Li Kaikai[1]
;
Zhang Jun[2]
;
Lin Dongmei[3]
;
Wang Da-Wei[4]
;
Li Baohua[5]
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浏览/下载:66/0
  |  
提交时间:2019/04/22
Improved NOx Reduction in the Presence of SO2 by Using Fe2O3-Promoted Halloysite-Supported CeO2-WO3 Catalysts
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2019, 卷号: 53, 页码: 938-945
作者:
Kang, Lin[1]
;
Han, Lupeng[2]
;
He, Jiebing[3]
;
Li, Hongrui[4]
;
Yan, Tingting[5]
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浏览/下载:16/0
  |  
提交时间:2019/04/22
Naringenin Cocrystals Prepared by Solution Crystallization Method for Improving Bioavailability and Anti-hyperlipidemia Effects
期刊论文
AAPS PharmSciTech, 2019, 卷号: 20, 页码: 115
作者:
Cui Wenxia[1]
;
He Zehui[2]
;
Zhang Yongtai[3]
;
Fan Qiangyuan[4]
;
Feng Nianping[5]
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  |  
浏览/下载:77/0
  |  
提交时间:2019/04/22
anti-hyperlipidemia
bioavailability
co-crystals
dissolution
naringenin
GLI1 overexpression promotes gastric cancer cell proliferation and migration and induces drug resistance by combining with the AKT-mTOR pathway
期刊论文
Biomedicine & pharmacotherapy, 2019, 卷号: 111, 页码: 993-1004
作者:
Yao Yizhou[1]
;
Zhou Diyuan[2]
;
Shi Dongtao[3]
;
Zhang Hui[4]
;
Zhan Shenghua[5]
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  |  
浏览/下载:28/0
  |  
提交时间:2019/04/22
AKT
Drug-resistance
GLI1
Gastric cancer
Hedgehog pathway
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