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科研机构
上海药物研究所 [7]
山东大学 [6]
上海健康医学院 [5]
西安交通大学 [3]
华中师范大学 [2]
武汉大学 [2]
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期刊论文 [35]
会议论文 [3]
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2021 [2]
2020 [3]
2019 [4]
2018 [4]
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2016 [5]
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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone
期刊论文
ISCIENCE, 2020, 卷号: 23, 期号: 2, 页码: 46
作者:
Zhou, Chen
;
Zhang, Chi
;
Zhu, Hongwen
;
Liu, Zhijun
;
Su, Haixia
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  |  
浏览/下载:145/0
  |  
提交时间:2020/07/01
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593
作者:
Zhang, Xianglei
;
Dong, Guangyu
;
Li, Heng
;
Chen, Wuyan
;
Li, Jian
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Zhen
;
Jiang, Xiangrui
;
Zhang, Xianglei
;
Tian, Guanghui
;
Yang, Rulei
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  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Reconstructing the western boundary variability of the Western Pacific Subtropical High over the past 200years via Chinese cave oxygen isotope records
期刊论文
CLIMATE DYNAMICS, 2019, 卷号: 52, 期号: 5-6, 页码: 3741-3757
作者:
Zhao, Jingyao
;
Cheng, Hai
;
Yang, Yan
;
Tan, Liangcheng
;
Spoetl, Christoph
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/06/22
Speleothem
Oxygen isotopes
Asian Monsoon
WPSH
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
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  |  
浏览/下载:138/0
  |  
提交时间:2019/06/28
High-performance noncontact thermal diode via asymmetric nanostructures
期刊论文
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER, 2018, 卷号: 211, 页码: 1-8
作者:
Shen, Jiadong
;
Liu, Xianglei
;
He, Huan
;
Wu, Weitao
;
Liu, Baoan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/11/26
Nanostructure
Near-field thermal radiation
Doping silicon
Thermal diode
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