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LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020)
期刊论文
MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/11/04
Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
Molecular Cancer, 2021, 卷号: 20, 期号: 1
作者:
Zhang,Tao
;
Qu,Rong
;
Chan,Shingpan
;
Lai,Mengzhen
;
Tong,Linjiang
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
Spatial pattern and developing mechanism of railway geo-systems based on track gauge: A case study of Eurasia
期刊论文
JOURNAL OF GEOGRAPHICAL SCIENCES, 2020, 卷号: 30, 期号: 8, 页码: 1283-1306
作者:
Wang, Chengjin
;
Li, Xumao
;
Chen, Peiran
;
Xie, Yongshun
;
Liu, Weidong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2021/03/18
railway
railway geosystem
development mechanism
expansion mode
Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
期刊论文
MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15
作者:
Zhang, Tao
;
Qu, Rong
;
Chan, Shingpan
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer (NSCLC)
EGFR T790M
Small-molecule inhibitor
Drug resistance
Ack1
discoveryandbiologicalevaluationofn372methoxy44methylpiperazin1ylphenylamino4methyl2oxo2hpyrimido45d13oxazin14hylphenylacrylamideaspotentbrutonstyrosinekinaseinhibitors
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 3, 页码: 415
作者:
Lai Mengzhen
;
Song Peiran
;
Dou Dou
;
Diao Yanyan
;
Tong Linjiang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton’s tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Identifying microRNAs and Their Editing Sites in Macaca mulatta
期刊论文
CELLS, 2019, 卷号: 8, 期号: 7
作者:
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  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
miRNA
microRNA editing
Macaca mulatta
small RNA-seq
bioinformatics
ONECUT2 is a driver of neuroendocrine prostate cancer.
期刊论文
Nature communications, 2019, 卷号: 10, 期号: 1, 页码: 278
作者:
Guo, Haiyang*
;
Ci, Xinpei
;
Ahmed, Musaddeque
;
Hua, Junjie Tony
;
Soares, Fraser
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  |  
浏览/下载:24/0
  |  
提交时间:2019/12/23
Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
MEDCHEMCOMM, 2018, 卷号: 9, 期号: 4, 页码: 697-704
作者:
Chen, Haiyang
;
Song, Peiran
;
Diao, Yanyan
;
Hao, Yongjia
;
Dou, Dou
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
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