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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [9]
发表日期
2021 [1]
2020 [3]
2018 [5]
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A novel silicone derivative of natural osalmid (DCZ0858) exerts anti-multiple myeloma activity by promoting cell apoptosis and inhibiting cell cycle and mTOR signaling
期刊论文
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 卷号: 13, 期号: 10, 页码: 11439-11449
作者:
Bu, Wenxuan
;
Li, Bo
;
Feng, Lijin
;
Feng, Qilin
;
Hu, Ke
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/16
Multiple myeloma
DCZ0858
mTOR
bone marrow microenvironment
cell proliferation
cell apoptosis
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
期刊论文
Journal of Experimental & Clinical Cancer Research, 2020, 卷号: 39, 期号: 1
作者:
Hu,Liangning
;
Li,Bo
;
Chen,Gege
;
Song,Dongliang
;
Xu,Zhijian
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2020/07/01
Multiple myeloma
Drug-resistance
DNA damage response
Cell cycle
Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 卷号: 52, 期号: 4, 页码: 401-410
作者:
Xi, Mengyu
;
He, Wan
;
Li, Bo
;
Zhou, Jinfeng
;
Xu, Zhijian
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
DCZ0801
DLBCL
apoptosis
cell cycle
MAPK
Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2020, 卷号: 52, 期号: 4, 页码: 401-410
作者:
Xi, Mengyu
;
He, Wan
;
Li, Bo
;
Zhou, Jinfeng
;
Xu, Zhijian
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/24
DCZ0801
DLBCL
apoptosis
cell cycle
MAPK
Rafoxanide, an organohalogen drug, triggers apoptosis and cell cycle arrest in multiple myeloma by enhancing DNA damage responses and suppressing the p38 MAPK pathway
期刊论文
Cancer letters, 2018, 卷号: 444, 页码: 45-59
作者:
Xiao, Wenqin
;
Xu, Zhijian
;
Chang, Shuaikang
;
Li, Bo
;
Yu, Dandan
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 8, 页码: 782-792
作者:
Yu, Dandan
;
Zhang, Yong
;
Chen, Gege
;
Xie, Yongsheng
;
Xu, Zhijian
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2
期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 2, 页码: 823-834
作者:
Xie, Yongsheng
;
Li, Bo
;
Bu, Wenxuan
;
Gao, Lu
;
Zhang, Yong
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
mantle cell lymphoma
dihydrocelastrol
apoptosis
cell cycle
mTORC1
mTORC2
Dual inhibition of mTORC1/2 by DCZ0358 induces cytotoxicity in multiple myeloma and overcomes the protective effect of the bone marrow microenvironment
期刊论文
CANCER LETTERS, 2018, 卷号: 421, 页码: 135-144
作者:
Gao, Lu
;
Li, Bo
;
Yang, Guang
;
Liu, Peng
;
Lan, Xiucai
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
mTOR
Multiple myeloma
Bone marrow microenvironment
Apoptosis
targetingthepi3kaktmtorsignalingpathwaybypterostilbeneattenuatesmantlecelllymphomaprogression
期刊论文
actabiochimicaetbiophysicasinica, 2018, 卷号: 50, 期号: 8, 页码: 782
作者:
Yu Dandan
;
Zhang Yong
;
Chen Gege
;
Xie Yongsheng
;
Xu Zhijian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
PROTEIN-KINASE PATHWAY
CANCER IN-VITRO
TRANSDUCTION PATHWAYS
CYCLE ARREST
APOPTOSIS
ACTIVATION
PATHOGENESIS
INHIBITION
ANTICANCER
EXPRESSION
mantle cell lymphoma
pterostilbene
antiproliferative activity
PI3K/Akt/mTOR pathway
synergistic cytotoxicity
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