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合肥物质科学研究院 [28]
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武汉大学 [5]
中国农业科学院 [4]
复旦大学上海医学院 [4]
北京大学 [3]
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Quantitative palaeogeographical reconstruction of the North China Block during the Carboniferous and Permian transition: Implications for coal accumulation and source rock development
期刊论文
Palaeogeography, Palaeoclimatology, Palaeoecology, 2024, 卷号: 640, 页码: 112102
作者:
Shen, Boheng
;
Hou, Zhangshuai
;
Wang, Xiangdong
;
Wu, Qiong
;
Zhang, Hua(张华)
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/04/15
An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Wang, Beilei
;
Wu, Hong
;
Hu, Chen
;
Wang, Haizhen
;
Liu, Jing
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/25
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing
期刊论文
CELL METABOLISM, 2021, 卷号: 33, 期号: 10, 页码: 2004-+
作者:
Li, Yufeng
;
Xu, Junyu
;
Lu, Yuting
;
Bian, Hua
;
Yang, Lin
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/18
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML)
期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:
Wu, Jiaxin
;
Wang, Aoli
;
Li, Xixiang
;
Chen, Cheng
;
Qi, Ziping
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/11/27
BCR-ABL
PDGFR
chronic myeloid leukemia
kinase inhibitor
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:
Yun Wu
;
Beilei Wang
;
Junjie Wang
;
Qi S(亓爽)
;
Fengming Zou
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2020/10/20
Down-regulation of miR-200c attenuates Angll-induced cardiac hypertrophy via targeting the MLCK-mediated pathway
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 4
作者:
Hu, Shan
;
Cheng, Mian
;
Guo, Xin
;
Wang, Shun
;
Liu, Beilei
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/05
apoptosis
cardiac hypertrophy
miR-200c
myosin light chain kinase
reactive oxygen species
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models
期刊论文
CANCER LETTERS, 2019, 页码: 105-114
作者:
Lu, Tingting
;
Chen, Cheng
;
Wang, Aoli
;
Jiang, Zongru
;
Qi, Ziping
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/14
cKIT T670I mutant
Activation loop mutants
Drug resistance
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:
Liu, Xuesong
;
Wang, Beilei
;
Chen, Cheng
;
Jiang, Zongru
;
Hu, Chen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/11
ABL kinase
Kinase inhibitor
ABL mutant
CML
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:
Wang, Beilei
;
Wu, Jiaxin
;
Wu, Yun
;
Chen, Cheng
;
Zou, Fengming
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/12/25
CDK9
Kinase inhibitor
Structure-activity relationship
Leukemia
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: Vol.160, 页码: 61-81
作者:
Liu, Xiaochuan
;
Wang, Beilei
;
Wang, Junjie
;
Zhang, Yicong
;
Jiang, Zongru
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/04/24
ABL kinase
Kinase inhibitor
ABL mutant
CML
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