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江苏大学 [34]
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地质与地球物理研究所 [3]
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Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Nucleic Acids Analysis
期刊论文
SCIENCE CHINA-CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 171-203
作者:
Zhao, YX
;
Zuo, XL
;
Li, Q
;
Chen, F
;
Chen, YR
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/09/06
MEDIATED-ISOTHERMAL-AMPLIFICATION
ENHANCED RAMAN-SCATTERING
REAL-TIME PCR
LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY
ROLLING CIRCLE AMPLIFICATION
HYBRIDIZATION-CHAIN-REACTION
SEQUENCE-SPECIFIC DETECTION
CIRCULATING METHYLATED DNA
TANDEM REPEAT MARKERS
OF-CARE DIAGNOSTICS
Biochemical engineering in China
期刊论文
REVIEWS IN CHEMICAL ENGINEERING, 2019, 卷号: 35, 期号: 8, 页码: 929-993
作者:
Ding, Mingzhu
;
Chen, Biqiang
;
Ji, Xiaojun
;
Zhou, Jingwen
;
Wang, Huiyuan
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  |  
浏览/下载:36/0
  |  
提交时间:2020/03/24
Biochemical Engineering
Food Chemical Engineering
Industrial Biotechnology
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204
作者:
Zhou, Ting-ting
;
Zhao, Tong
;
Ma, Fei
;
Zhang, Yi-nan
;
Jiang, Jing
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  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
type 2 diabetes mellitus
hepatic gluconeogenesis
AMPK signaling pathway
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
prodrug
Petrogenesis and tectonic implications of Late Mesoproterozoic A(1)- and A(2)-type felsic lavas from the Huili Group, southwestern Yangtze Block
期刊论文
GEOLOGICAL MAGAZINE, 2019, 卷号: 156, 期号: 8, 页码: 1425-1439
作者:
Wang, Dong-Bing
;
Wang, Bao-Di
;
Yin, Fu-Guang
;
Sun, Zhi-Ming
;
Liao, Shi-Yong
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  |  
浏览/下载:60/0
  |  
提交时间:2019/09/26
A-type
back-arc setting
Late Mesoproterozoic
Western Yangtze Block
Gap-Tethered Au@AgAu Raman Tags for the Ratiometric Detection of MC-LR
期刊论文
ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 11, 页码: 7162-7172
作者:
Zhao, Yuan
;
Zheng, Fangjie
;
Ke, Wei
;
Zhang, Wei
;
Shi, Lixia
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  |  
浏览/下载:77/0
  |  
提交时间:2019/07/12
A new conodont biozone classification of the Ordovician System in South China
期刊论文
PALAEOWORLD, 2019, 卷号: 28, 期号: 1-2, 页码: 173-186
作者:
Wang, Zhi-Hao (王志浩)
;
Zhen, Yong Yi
;
Bergstrom, Stig M.
;
Wu, Rong-Chang (吴荣昌))
;
Zhang, Yuan-Dong (张元动)
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/05/22
Ordovician
Conodonts
Biostratigraphy
South China
Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury
期刊论文
BMC medicine, 2019, 卷号: 17, 页码: 42
作者:
Bei Yihua[1]
;
Pan Li-Long[2]
;
Zhou Qiulian[3]
;
Zhao Cuimei[4]
;
Xie Yuan[5]
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/04/22
Apoptosis
CRAMP
Cardiomyocyte
Cathelicidin
Ischemia/reperfusion injury
LL-37
Down-regulation of JMJD5 suppresses metastasis and induces apoptosis in oral squamous cell carcinoma by regulating p53/NF-κB pathway.
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 卷号: Vol.109, 页码: 1994-2004
作者:
Yao Yuan
;
Zhou Wen-Ying
;
He Rui-Xin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Apoptosis
JMJD5
Migration
and
invasion
Oral
squamous
cell
carcinoma
(OSCC)
p53/NF-κB
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice.
期刊论文
Acta pharmacologica Sinica, 2019
作者:
Ting-Ting Zhou
;
Tong Zhao
;
Fei Ma
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/13
(E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)
4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)
AMPK signaling pathway
hepatic gluconeogenesis
prodrug
type 2 diabetes mellitus
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