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科研机构
上海药物研究所 [8]
复旦大学上海医学院 [7]
中国科学院大学 [1]
中国农业科学院 [1]
山东大学 [1]
上海大学 [1]
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期刊论文 [16]
专利 [2]
会议论文 [1]
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2021 [1]
2019 [1]
2018 [3]
2017 [5]
2016 [1]
2014 [1]
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Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:
He, Qian
;
Wei, Yuanyuan
;
Liu, Xiao
;
Ye, Rongrong
;
Kong, Linghui
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2021/11/04
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:
Xiao, Li
;
Wang, Yujun
;
Zhang, Mumei
;
Wu, Weiwei
;
Kong, Linghui
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  |  
浏览/下载:97/0
  |  
提交时间:2020/07/01
Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12
作者:
Xu, Yulong
;
Yang, Xicheng
;
Chen, Yiyi
;
Chen, Hao
;
Sun, Huijiao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Proteasome inhibitors
Topology-based
Scaffold hopping
Bortezomib
Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 卷号: 16, 期号: 27
作者:
Xu, Yulong
;
Chen, Hao
;
Li, Wei
;
Xie, Qiong
;
Yu, Linqian
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha 7 nAChR activities
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160
作者:
Yang, Xicheng
;
Shen, Jian
;
Jiang, Lulu
;
Li, Wei
;
Yu, Mingcheng
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Piperidine derivatives
Ls-AChBP
Cocrystallization
alpha 7 nAChR
Molecular docking
Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands
期刊论文
中国药理学报, 2017, 卷号: 38, 期号: 1
作者:
Shen Jian
;
Yang Xicheng
;
Yu Mingcheng
;
Xiao Li
;
Zhang Xunjie
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
a7 nAChR
acetylcholine-binding protein ligands
piperidine derivatives
molecular modeling
psychotic disorders
Microwave-Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi-Substituted Isoquinolines
期刊论文
CHEMISTRYSELECT, 2017, 卷号: 2, 期号: 26
作者:
Xu, Yulong
;
Chen, Hao
;
Li, Wei
;
Xie, Qiong
;
Yu, Linqian
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
C(sp(3))-H bond
Isoquinolines
Microwave-assisted
Radical
Vinyl isocyanides
Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 卷号: 15, 期号: 47
作者:
Xue, Dengqi
;
Chen, Hao
;
Xu, Yulong
;
Yu, Haihua
;
Yu, Linqian
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  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Concise Synthesis of Polycyclic Indoline Scaffolds through an In-III-Catalyzed Formal [4+2] Annulation of 2,3-Disubstituted Indoles with o-Aminobenzyl Alcohols
期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 期号: 18
作者:
Luo, Mupeng
;
Chen, Jianxin
;
Yu, Linqian
;
Wei, Wanguo
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
Nitrogen heterocycles
Fused-ring systems
Cycloaddition
Diastereoselectivity
Indium
Metal-free sulfonylation of quinones with sulfonyl hydrazides in water: Facile access to mono-sulfonylated hydroquinones
期刊论文
TETRAHEDRON, 2017, 卷号: 73, 页码: 2760-2765
作者:
Li, Bin[1]
;
Li, Yaqin[2]
;
Yu, Linqian[3]
;
Wu, Xiaoyu[4]
;
Wei, Wanguo[5]
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/04/24
Metal-free
Quinone
Sulfonylation
Phenol
Hydroquinone
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