×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
复旦大学上海医学院 [5]
中南大学 [3]
厦门大学 [2]
四川大学 [2]
上海中医药大学 [2]
南华大学 [1]
更多...
内容类型
期刊论文 [21]
会议论文 [1]
学位论文 [1]
发表日期
2019 [1]
2017 [2]
2016 [3]
2015 [6]
2014 [4]
2013 [2]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共23条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
作者升序
作者降序
题名升序
题名降序
发表日期升序
发表日期降序
提交时间升序
提交时间降序
Epidermal growth factor receptor mimotope alleviates renal fibrosis in murine unilateral ureteral obstruction model
期刊论文
CLINICAL IMMUNOLOGY, 2019, 卷号: 205
作者:
Yang, Lin
;
Yuan, Haoran
;
Yu, Ying
;
Yu, Nan
;
Ling, Lilu
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/05
Epidermal growth factor receptor
Macrophage
Mimotope
Renal fibrosis
CD9
Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Liu, Huihui
;
Li, Wan
;
He, Qing
;
Xue, Jinjuan
;
Wang, Jiyun
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2018/01/10
NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease
期刊论文
MEDIATORS OF INFLAMMATION, 2017
作者:
Guo, Honglei
;
Bi, Xiao
;
Zhou, Ping
;
Zhu, Shijian
;
Ding, Wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
A porcine model of relief of unilateral ureteral obstruction: study on self-repairing capability over multiple time points
期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2016, 卷号: 419, 期号: 1-2
作者:
Luo, Manyu
;
Liu, Yingying
;
Sun, Jing
;
Miao, Lining
;
Ji, Lei
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Kidney
Fibrosis
Ureteral obstruction
Animal model
Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction
期刊论文
2016, 卷号: 44, 期号: [db:dc_citation_issue], 页码: 698
作者:
Cai, Xiang-Ran[1]
;
Yu, Juan[2]
;
Zhou, Qing-Chun[3]
;
Du, Bin[4]
;
Feng, You-Zhen[1]
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction
期刊论文
Journal of Magnetic Resonance Imaging, 2016, 卷号: 44, 期号: 3, 页码: 698-706
作者:
Cai, Xiang-Ran*
;
Yu, Juan
;
Zhou, Qing-Chun
;
Du, Bin
;
Feng, You-Zhen
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/27
*diffusion-weighted imaging
*hydronephrosis
*intravoxel incoherent motion
*renal interstitial fibrosis
*unilateral ureteral obstruction
Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction
期刊论文
PLOS ONE, 2015, 卷号: 10, 期号: 6, 页码: e0129283
作者:
Liu, Chunyan
;
Mei, Wenjuan
;
Tang, Juan
;
Yuan, Qiongjing
;
Huang, Ling
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/03
Kidneys,Collagens,Fibrosis,Macrophages,Inflammation,Transcription factors,Fibroblasts,Phosphorylation
Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model
期刊论文
Experimental and Therapeutic Medicine, 2015, 卷号: 9, 期号: 3, 页码: 737-743
作者:
Tang, Jin
;
Jiang, Xianzhen
;
Zhou, Yihong
;
Xia, Bing
;
Dai, Yingbo*
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
adenosine
cytokines
renal interstitial fibrosis
unilateral ureteral obstruction model
alpha-smooth muscle actin
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:
Zhang, Lei
;
Xu, Xuan
;
Yang, Ruhao
;
Chen, Jingwen
;
Wang, Shixuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However
the underlying molecular mechanism remains unclear. In this study
we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3
and inhibited the expression of fibronectin
alpha-smooth muscle actin (α-SMA)
and collagen I in cultured NRK-49F cells. S3I-201
an STAT3 inhibitor
also suppressed the expression of fibronectin
α-SMA
and collagen I in cultured NRK-49F cells. Mechanistically
paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore
paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin
α-SMA
and collagen I
and suppressed the infiltration of macrophages and production of TNF-α
IL-1β
TGF-β
and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation
consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis
and inhibition of proinflammatory cytokine production.
Ameliorating Effect of Klotho on Endoplasmic Reticulum Stress and Renal Fibrosis Induced by Unilateral Ureteral Obstruction
期刊论文
IRANIAN JOURNAL OF KIDNEY DISEASES, 2015, 卷号: 9, 期号: 4, 页码: 291-297
作者:
Liu, Qi-Feng[1]
;
Ye, Jian-Ming[2]
;
Deng, Zhi-Yong[3]
;
Yu, Li-Xia[4]
;
Sun, Qiang[5]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/24
Endoplasmic Reticulum Stress
klotho protein
chronic kidney disease
animal model
©版权所有 ©2017 CSpace - Powered by
CSpace