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GPR30 Activation Promotes the Progression of Gastric Cancer and Plays a Significant Role in the Anti-GC Effect of Huaier
期刊论文
JOURNAL OF ONCOLOGY, 2022, 卷号: 2022
作者:
Wang, Xiao-feng
;
Hu, Can
;
Mo, Shao-Wei
;
Xu, Jing-Li
;
Liu, Yan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/05/16
A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
A phase I study of the safety and activity of K-001 in patients with advanced pancreatic ductal adenocarcinoma
期刊论文
BMC Cancer, 2021, 卷号: 21, 期号: 1
作者:
Cui,Jiujie
;
Yang,Haiyan
;
Liu,Jue
;
Chen,Donghui
;
Hu,Jiong
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/06/15
Pancreatic ductal adenocarcinoma
Phase I study
Safety
K-001
Clinical trial
Exploring the concepts and practices of advanced breast cancer treatment: a narrative review
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9
作者:
Wang, Xiaojia
;
Shao, Xiying
;
Huang, Jian
;
Lei, Lei
;
Huang, Yuan
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  |  
浏览/下载:42/0
  |  
提交时间:2021/06/15
Metastatic breast cancer (MBC)
treatment
cure
molecular types
targeted therapy
Tolerability, Pharmacokinetic, and Pharmacodynamic Profiles of Henagliflozin, a Novel Selective Inhibitor of Sodium-Glucose Cotransporter 2, in Healthy Subjects Following Single- and Multiple-dose Administration
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 2, 页码: 396-409
作者:
Zhang, Yi-fan
;
Liu, Yan-mei
;
Yu, Chen
;
Wang, Ya-ting
;
Zhan, Yan
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2021/05/24
diabetes
henagliflozin
pharmacodynamics
pharmacokinetics
SGLT-2 inhibitors
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Development of Taccalonolide AJ-Hydroxypropyl-beta-Cyclodextrin Inclusion Complexes for Treatment of Clear Cell Renal-Cell Carcinoma
期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 23, 页码: 14
作者:
Han, Jing
;
Zhang, Siwang
;
Niu, Junxin
;
Zhang, Chunli
;
Dai, Weichen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
taccalonolide AJ
microtubule stabilizer
hydroxypropyl-β
-cyclodextrin
inclusion complex
clear-cell renal-cell carcinoma
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors
期刊论文
CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+
作者:
Li, Huiping
;
Liu, Rongrui
;
Shao, Bin
;
Ran, Ran
;
Song, Guohong
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/24
Phase I
PARP inhibitor (fluzoparib)
solid tumor
pharmacokinetics
safety
antitumor activity
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:
Chen, Cheng
;
Cheng, Chuan-dong
;
Wu, Hong
;
Wang, Zuo-wei
;
Wang, Li
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
glioblastoma
osimertinib
temozolamide
MAPK-signaling pathway
MNK
eukaryotic translation initiation factor 4E
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