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上海药物研究所 [17]
湖南大学 [5]
四川大学 [4]
山东大学 [3]
大连化学物理研究所 [2]
暨南大学 [2]
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期刊论文 [37]
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1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:
Zhang, Yu
;
Goto, Masuo
;
Oda, Akifumi
;
Hsu, Pei-Ling
;
Guo, Ling-Li
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/07/29
aspidosperma-type
monoterpenoid indole alkaloids
antiproliferative activity
tubulin inhibitor
Bousigonia mekongensis
Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 73-86
作者:
Zhao, Wei
;
He, Long
;
Xiang, Tian-Le
;
Tang, Ya-Jie
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Tubulin
Colchicine domain
Podophyllotoxin
Binding affinity
Nanomolar-potency antitumor activity
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
European Journal of Medicinal Chemistry, 2019, 页码: 73-86
作者:
Zhao W.
;
He L.
;
Xiang T.-L.
;
Tang Y.-J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Binding affinity
Colchicine domain
Nanomolar-potency antitumor activity
Podophyllotoxin
Tubulin
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.163, 页码: 428-442
作者:
Wenlong Li
;
Wen Shuai
;
Honghao Sun
;
Feijie Xu
;
Yi Bi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/13
Quinoline
Indole
Microtubule
Tubulin
inhibitor
Colchicine
binding
site
Antitumor
Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site
期刊论文
Bioorganic Chemistry, 2019, 卷号: Vol.85, 页码: 49-59
作者:
Wenlong Li
;
Honghao Sun
;
Feijie Xu
;
Wen Shuai
;
Jie Liu
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/12/13
Tubulin
inhibitor
Vinyl
sulfone
Indole
Colchicine
site
Drug-likeness
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
Experimental and Simulation Identification of Xanthohumol as an Inhibitor and Substrate of ABCB1
期刊论文
APPLIED SCIENCES-BASEL, 2018, 卷号: 8, 期号: 5
作者:
Liu, Fangming
;
Hoag, Hannah
;
Wu, Chun
;
Liu, Haizhou
;
Yin, Hua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/08/19
xanthohumol
doxorubicin resistance
synergism
ABCB1
Experimental and Simulation Identification of Xanthohumol as an Inhibitor and Substrate of ABCB1
期刊论文
APPLIED SCIENCES-BASEL, 2018, 卷号: 8, 期号: 5, 页码: 681:1-11
作者:
Liu, Fangming
;
Hoag, Hannah
;
Wu, Chun
;
Liu, Haizhou
;
Yin, Hua
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2018/12/07
xanthohumol
doxorubicin resistance
synergism
ABCB1
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 817-842
作者:
Zhou, Pengfei
;
Liang, Yuru
;
Zhang, Hao
;
Jiang, Hao
;
Feng, Kechang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
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