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上海药物研究所 [10]
武汉大学 [7]
合肥物质科学研究院 [5]
山东大学 [4]
复旦大学上海医学院 [4]
厦门大学 [2]
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期刊论文 [48]
学位论文 [1]
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Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wang, Zuo-wei
;
Zou, Feng-ming
;
Wang, Ao-li
;
Yang, Jing
;
Jin, Rui
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/12/22
AZD4547
RIPK1
inhibitors
SIRS model
anti-necroptosis
Data science approaches to confronting the COVID-19 pandemic: a narrative review
期刊论文
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2022, 卷号: 380, 期号: 2214, 页码: 20
作者:
Zhang, Qingpeng
;
Gao, Jianxi
;
Wu, Joseph T.
;
Cao, Zhidong
;
Zeng, Daniel Dajun
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/12/28
infectious disease
mathematical modelling
data science
big data
COVID-19
A deep learning method for repurposing antiviral drugs against new viruses via multi-view nonnegative matrix factorization and its application to SARS-CoV-2
期刊论文
BRIEFINGS IN BIOINFORMATICS, 2022, 卷号: 23, 期号: 1, 页码: 1-16
作者:
Su, XR (Su, Xiaorui) [1]
;
Hu, L (Hu, Lun) [1]
;
You, ZH (You, Zhuhong) [2]
;
Hu, PW (Hu, Pengwei) [1]
;
Wang, L (Wang, Lei) [3]
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/05/06
SARS-CoV-2
drugrepositioning
constrained multi-view nonnegative matrix factorization
deeplearning
graphconvolutionalnetwork
Programmable Repurposing of Existing Drugs as Pharmaceutical Elements for the Construction of Aptamer-Drug Conjugates
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2021, 卷号: 13
作者:
Gao, Fei
;
Zhou, Jinming
;
Sun, Yang
;
Yang, Cai
;
Zhang, Shiyan
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  |  
浏览/下载:51/0
  |  
提交时间:2021/04/26
aptamer
pharmaceutical elements
solid-phase synthesis
targeted therapy
drug delivery
DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration
期刊论文
BRIEFINGS IN BIOINFORMATICS, 2021, 卷号: 22, 期号: 5
作者:
Wang, Yongcui
;
Yang, Yingxi
;
Chen, Shilong
;
Wang, Jiguang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/11/18
drug repurposing
multi-omics data sources
kernel-based data integration
machine learning
cancer precision medicine
Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 卷号: 117, 期号: 44, 页码: 27381-27387
作者:
Li, Zhe
;
Li, Xin
;
Huang, Yi-You
;
Wu, Yaoxing
;
Liu, Runduo
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  |  
浏览/下载:76/0
  |  
提交时间:2020/12/24
virtual screening
SARS-CoV-2
drug repurposing
free energy perturbation
main protease
Repurposing of Kinase Inhibitors for Treatment of COVID-19
期刊论文
PHARMACEUTICAL RESEARCH, 2020, 卷号: 37
作者:
Weisberg, Ellen
;
Parent, Alexander
;
Yang, Priscilla L.
;
Sattler, Martin
;
Liu, Qingsong
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  |  
浏览/下载:36/0
  |  
提交时间:2020/10/26
Coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
kinase inhibitors
pharmacokinetics
antiviral therapy
COVID-19
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 3, 页码: 434-446
作者:
Feng, Hongxuan
;
Hu, Linghao
;
Zhu, Hongwen
;
Tao, Lingxue
;
Wu, Lei
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Blood-brain barrier
Brain ischemia
Cell cycle
Inflammation
Neuroprotection
Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting
期刊论文
THERANOSTICS, 2020, 卷号: 10, 期号: 14, 页码: 6384-6398
作者:
Ren, Liting
;
Feng, Wenya
;
Shao, Jie
;
Ma, Juan
;
Xu, Ming
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/09/14
diethyldithiocarbamate
DSF-Cu nanocomplex
light-triggered nuclear targeting
metastasis
epithelial-mesenchymal transition
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