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中国医学科学院 北京... [4]
上海药物研究所 [2]
上海中医药大学 [2]
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期刊论文 [11]
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2021 [1]
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Chemistry [1]
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human
期刊论文
2017, 卷号: 8, 页码: 683
作者:
Yang, Fen
;
Wang, Baolian
;
Liu, Zhihao
;
Xia, Xuejun
;
Wang, Weijun
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
buagafuran
pharmacokinetics
pharmacodynamic
physiologically based pharmacokinetic (PBPK) modeling
in silico modeling
clinical pharmacokinetics
Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin
期刊论文
2017, 卷号: 106, 期号: 8, 页码: 2144-2151
作者:
Amaraneni, Manoj
;
Pang, Jing
;
Bruckner, James V.
;
Muralidhara, Srinivasa
;
Mortuza, Tanzir B.
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/03
absorption
blood-brain barrier
equilibrium
kinetics
osmotic pumps
permeability
pharmacokinetic/pharmacodynamics models
pharmacokinetics
physiologically based pharmacokinetic modeling
tissue partition
A Three-Pulse Release Tablet for Amoxicillin: Preparation, Pharmacokinetic Study and Physiologically Based Pharmacokinetic Modeling
期刊论文
PLOS ONE, 2016, 卷号: 11, 期号: 8
作者:
Li, Jin
;
Chai, Hongyu
;
Li, Yang
;
Chai, Xuyu
;
Zhao, Yan
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human
期刊论文
2015, 卷号: 77, 页码: 265-272
作者:
Wang, Baohan
;
Liu, Zhihao
;
Li, Dan
;
Yang, Shuang
;
Hu, Jinping
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
Bicyclol
Pharmacokinetic
Dog
Human
PBPK
Relative contributions of the major human CYP450 to the metabolism of icotinib and its implication in prediction of drug-drug interaction between icotinib and CYP3A4 inhibitors/inducers using physiologically based pharmacokinetic modeling
期刊论文
2015, 卷号: 11, 期号: 6, 页码: 857-868
作者:
Chen, Jia
;
Liu, Dongyang
;
Zheng, Xin
;
Zhao, Qian
;
Jiang, Ji
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/13
contribution of CYP450s
drug-drug interaction
human liver microsome
icotinib
physiologically based pharmacokinetic
supersome
Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective
期刊论文
AAPS JOURNAL, 2014, 卷号: 16, 期号: 6
作者:
Yu, Guo
;
Zheng, Qing-Shan
;
Li, Guo-Fu
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
gastric emptying
gastrointestinal pH
neonates
physiologically based pharmacokinetic modeling
small intestinal transit time
Metabolism of Nanomaterials in Vivo: Blood Circulation and Organ Clearance
期刊论文
ACCOUNTS OF CHEMICAL RESEARCH, 2013, 卷号: 46, 期号: 3, 页码: 761-769
作者:
Wang B(汪冰)
;
He X(何潇)
;
Zhang ZY(张智勇)
;
Wang, B
;
He, X
收藏
  |  
浏览/下载:113/0
  |  
提交时间:2016/04/08
Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling
期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 11
作者:
Li, Guo-fu
;
Wang, Kun
;
Chen, Rui
;
Zhao, Hao-ru
;
Yang, Jin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
bisoprolol
whole-body physiologically based pharmacokinetic model
drug absorption
drug distribution
renal function impairment
Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling
期刊论文
Acta pharmacologica Sinica, 2012, 卷号: 33, 页码: 1359-71
作者:
Li Guo-fu[1]
;
Wang Kun[2]
;
Chen Rui[3]
;
Zhao Hao-ru[4]
;
Yang Jin[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/04/30
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