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上海药物研究所 [6]
上海营养与健康研究所 [3]
北京大学 [2]
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期刊论文 [20]
学位论文 [2]
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cell biolo... [1]
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Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9
作者:
Liu, Xiao
;
Yang, Su
;
Hart, Jonathan R.
;
Xu, Yingna
;
Zou, Xinyu
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/04
phosphoinositide 3-kinase (PI3K)
activation
inhibition
activity-dependent conformational changes
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/AktSREBP2 signaling pathway to influence lipid metabolism in HepG2 cells.
期刊论文
International journal of molecular medicine, 2019, 卷号: 43, 期号: 5, 页码: 2055-2063
作者:
Xiao, Jun
;
Bai, Xue-Qin
;
Liao, Ling
;
Zhou, Min
;
Peng, Juan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/27
HepG2 cells
Hydrogen sulfide
Lipid metabolism
Low-density lipoprotein receptor
Phosphoinositide 3-kinase/protein kinase B
Proprotein convertase subtilisin/kexin type 9
Sterol regulatory element-binding protein 2
High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822
作者:
Wang, Jia
;
Gong, Grace Qun
;
Zhou, Yan
;
Lee, Woo-Jeong
;
Buchanan, Christina Maree
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  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
high throughput screening
PI3 kinase
PI3K alpha H1047R
inhibitors
molecular modeling
Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
期刊论文
MOLECULAR CELL, 2018, 卷号: 71, 期号: 2, 页码: 201-+
作者:
Zhang, Yajuan
;
Wang, Xiongjun
;
Cai, Guoqing
;
Liu, Ruilong
;
Gao, Hong
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2019/04/28
Tumor-associated Macrophages
Cancer-cell Metabolism
Blood-brain-barrier
Phosphoglycerate Kinase
Human Glioblastoma
Microenvironment
Progression
Expression
Pkm2
Pdk1
Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway.
期刊论文
PLOS ONE, 2017
作者:
Zhang, Cui
;
Ruan, Qingguo
;
Chen, Youhai H
;
Geng, Wenwen
;
Fan, Tingting
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2018/02/02
The role of GPR1 signaling in mice corpus luteum
期刊论文
JOURNAL OF ENDOCRINOLOGY, 2016
作者:
Yang, Ya-Li
;
Ren, Li-Rong
;
Sun, Li-Feng
;
Huang, Chen
;
Xiao, Tian-Xia
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2017/01/16
The effect of local delivery of adiponectin from biodegradable microsphere-scaffold composites on new bone formation in adiponectin knockout mice
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2016
Li, Dan
;
Guo, Yuan
;
Lu, Hui
;
Wang, Ren
;
Hu, Hong-cheng
;
Lu, Song-he
;
Li, Xue-fen
;
Li, Zi-chen
;
Wu, Yu-wei
;
Tang, Zhi-hui
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/04
OSTEOGENIC DIFFERENTIATION
TISSUE REGENERATION
SIGNALING PATHWAY
EXTRACELLULAR-MATRIX
EXTRACTION SOCKETS
CONTROLLED-RELEASE
TOOTH EXTRACTION
MINERAL DENSITY
IN-VITRO
INSULIN
iTRAQ Protein Profile Differential Analysis of Dormant and Germinated Grassbur Twin Seeds Reveals that Ribosomal Synthesis and Carbohydrate Metabolism Promote Germination Possibly Through the PI3K Pathway
期刊论文
PLANT AND CELL PHYSIOLOGY, 2016, 卷号: 57, 期号: 6, 页码: 1244-1256
作者:
Zhang, Guo-Liang
;
Zhu, Yue
;
Fu, Wei-Dong
;
Wang, Peng
;
Zhang, Rui-Hai
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2016/12/06
Grassbur
Germination and dormancy
Insulin-like growth factor
iTRAQ
Proteomic analysis
Ribosomal protein
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review)
期刊论文
ONCOLOGY REPORTS, 2015, 卷号: 34, 期号: 2, 页码: 547-554
作者:
Luo, Xiangjian
;
Yu, Xinfang
;
Liu, Sufang
;
Deng, Qipan
;
Liu, Xiaolan
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2015/12/17
natural products
grifolin
neoalbaconol
epigallocatechin-3-gallate
cancer prevention
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