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上海药物研究所 [13]
昆明动物研究所 [2]
北京大学 [1]
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中国科学院大学 [1]
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期刊论文 [21]
学位论文 [2]
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Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C-60 Nanoparticles via in Vitro and in Silico Assays
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 22, 页码: 18626-18638
作者:
Liu, Yanyan
;
Yan, Bing
;
Winkler, David A.
;
Fu, Jianjie
;
Zhang, Aigian
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2018/07/26
C-60 Nanoparticle
Acetylcholinesterase
Competitive Inhibition
Peripheral Anionic Site
Quantitative Nanostructure-activity Relationship
Molecular Docking
Site-directed Mutation
Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C-60 Nanoparticles via in Vitro and in Silico Assays
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 22, 页码: 18626-18638
作者:
Liu, Yanyan
;
Yan, Bing
;
Winkler, David A.
;
Fu, Jianjie
;
Zhang, Aigian
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/12
C-60 nanoparticle
acetylcholinesterase
competitive inhibition
peripheral anionic site
quantitative nanostructure-activity
relationship
molecular docking
site-directed mutation
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex
期刊论文
PROTEIN SCIENCE, 2016, 卷号: 25, 期号: 6, 页码: 1096-1114
作者:
Dym, Orly
;
Song, Wanling
;
Felder, Clifford
;
Roth, Esther
;
Shnyrov, Valery
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
polyethylene glycol
structure-based drug discovery
acetylcholinesterase
methylene blue
decamethonium
Microbial community changes along the active seepage site of one cold seep in the Red Sea
期刊论文
FRONTIERS IN MICROBIOLOGY, 2015, 卷号: 6, 期号: 1
作者:
Wang, Yong
;
Cao, Huiluo
;
Zhang, Weipeng
;
Qian, Pei-Yuan
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  |  
浏览/下载:20/0
  |  
提交时间:2015/12/01
Cold Seep
Red Sea
16s Rrna Gene
Pyrosequencing
Ammonia Oxidizing Archaea
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase
期刊论文
Bioorganic and Medicinal Chemistry, 2014, 卷号: 22, 期号: 17, 页码: 4784-4791
作者:
Sun, Qi
;
Peng, Da-Yong
;
Yang, Sheng-Gang
;
Zhu, Xiao-Lei
;
Yang, Wen-Chao*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
AD
Alzheimer’s disease
AChE
acetylcholinesterase
BChE
butylcholinesterase
ACh
acetylcholine
Aβ
amyloid-β
CAS
catalytic active site
PAS
peripheral active site
MD
molecular dynamics
ATC
acetylthiocholine
ESI-MS
electrospray ionisation mass spectrometry
DMF
dimethylformamide
DTNB
5′,5′-Dithio-bis(2-nitrobenzoic acid)
LGA
Lamarkian genetic algorithm
EDCI
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
HOBt
N-hydroxybenzotriazole
PyBOP
benzotriazole-1-yl-oxytripyrrolidino-phosphonium hexafluorophosphate
Alzheimer’s disease
Coumarin
Acetylcholinesterase inhibitor
Butylcholinesterase inhibitor
化合物DB-02和SJP-L-5体外抗HIV-1活性及耐药性机制研究
学位论文
博士, 北京: 中国科学院研究生院, 2013
作者:
张兴杰
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2014/02/11
DB-02
S-DABO
S-DACO
耐药性
HIV-1
SJP-L-5
木脂素
非核苷类
逆转录酶抑制剂
五味子科
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 63, 页码: 95-103
作者:
Xing, Weiqiang
;
Fu, Yan
;
Shi, Zhangxing
;
Lu, Dong
;
Zhang, Haiyan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Pyridazinone
Acetylcholinesterase
Alzheimer's disease
Docking study
Supramolecular Self-Assembly of 1D and 3D Heterometallic Coordination Polymers with Triruthenium Building Blocks
期刊论文
chemistry a european journal, 2012
Chan, Sharon Lai-Fung
;
Gao, Song
;
Chui, Stephen Sin-Yin
;
Shek, Lam
;
Huang, Jie-Sheng
;
Che, Chi-Ming
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/11/12
coordination polymers
hydrothermal synthesis
metal-metal interactions
ruthenium
self-assembly
EFFECTIVE CORE POTENTIALS
METAL-ORGANIC FRAMEWORKS
ONE-DIMENSIONAL POLYMERS
MULTIPLE BONDS
MOLECULAR CALCULATIONS
ELECTRONIC-STRUCTURE
CRYSTAL-STRUCTURE
ACTIVE-SITE
COMPLEXES
TRINUCLEAR
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