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科研机构
上海药物研究所 [11]
复旦大学上海医学院 [4]
北京大学 [3]
兰州理工大学 [1]
中国科学院大学 [1]
中国农业科学院 [1]
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期刊论文 [21]
会议论文 [1]
其他 [1]
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2021 [1]
2018 [1]
2017 [3]
2016 [8]
2015 [1]
2014 [5]
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biochemist... [1]
biophysics [1]
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3 beta (GSK-3 beta)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20
作者:
Gao, Yang
;
Zhang, Peng
;
Cui, Anfeng
;
Ye, De-Yong
;
Xiang, Meng
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Glycogen synthase kinase 3 beta
Sirtuin 1
Non-ATP competitive inhibitors
Benzothiazepinones
Inflammation
LX2343 alleviates cognitive impairments in AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 8, 页码: 1104-1119
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Wang, Yi-yang
;
Xu, Xin
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
Alzheimer's disease
LX2343
cognitive deficits
oxidative stress
tauopathy
mitochondria
GSK-3 beta inhibitor
neuroprotection
ICV-STZ rats
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3 beta inhibitors for the treatment of ovarian cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135
作者:
Gao, Yang
;
Ye, De-Yong
;
Zhou, Wei-Cheng
;
Chu, Yong
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  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Glycogen synthase kinase 3 beta
Non-ATP competitive inhibitors
Benzothiazinones
Ovarian cancer
Antiproliferative activities
Structure of a Pancreatic ATP-Sensitive Potassium Channel
期刊论文
CELL, 2017
Li, Ningning
;
Wu, Jing-Xiang
;
Ding, Dian
;
Cheng, Jiaxuan
;
Gao, Ning
;
Chen, Lei
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
K+-CHANNEL
SULFONYLUREA RECEPTOR
MOLECULAR-BASIS
P-GLYCOPROTEIN
GLIBENCLAMIDE BINDING
ADENINE-NUCLEOTIDES
INSULIN-SECRETION
MEMBRANE-PROTEINS
CRYSTAL-STRUCTURE
ATOMIC-STRUCTURE
Small molecule lx2343 ameliorates cognitive deficits in ad model mice by targeting both amyloid beta production and clearance
期刊论文
Acta pharmacologica sinica, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/05/09
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (lx2343)
Streptozotocin
Amyloid beta
Pi3k
Autophagy
App/ps1 transgenic mice
Cognitive deficit
Bace1
Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid beta production and clearance
期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 10, 页码: 1281-1297
作者:
Guo, Xiao-dan
;
Sun, Guang-long
;
Zhou, Ting-ting
;
Xu, Xin
;
Zhu, Zhi-yuan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
N-(1,3-benzodioxol-5-yl)-2-[5-chloro-2-methoxy(phenylsulfonyl)anilino]acetamide (LX2343)
streptozotocin
amyloid beta
BACE1
PI3K
autophagy
APP/PS1 transgenic mice
cognitive deficit
A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 8, 页码: 9389-9404
作者:
Chen, Gang
;
Liu, Junhua
;
Chen, Wantao
;
Xu, Qin
;
Xiao, Meng
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
multi-drug resistance
ABCB1
chemotherapy
apoptosis
panax ginseng
Discovery of Non-ATP-Competitive Inhibitors of Polo-like Kinase1
期刊论文
CHEMMEDCHEM, 2016
Yun, Taikangxiang
;
Qin, Tan
;
Liu, Ying
;
Lai, Luhua
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/03
inhibitors
kinase domain
non-ATP binding site
polo-like kinase1
virtual screening
1 PLK1 INHIBITORS
P38 MAP KINASE
CANCER-THERAPY
BINDING-SITE
BOX DOMAIN
PROTEIN
POLO-LIKE-KINASE-1
IDENTIFICATION
APOPTOSIS
DESIGN
Discovery of Non-ATP-Competitive Plk1 Inhibitors
其他
2016-01-01
Taikangxiang Yun
;
Tan Qin
;
Ying Liu
;
Luhua Lai
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2017/12/03
Inhibitors
Kinase domain
Non-ATP binding site
Polo-like kinase 1
Inhibitors
Kinase domain
Non-ATP binding site
Polo-like kinase 1
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