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The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
肠道共生菌对宿主身心健康的影响及机制研究
学位论文
博士, 北京: 中国科学院研究生院, 2014
作者:
罗佳
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  |  
浏览/下载:117/0
  |  
提交时间:2016/04/29
肠道共生菌群
肠–脑轴
焦虑
抑郁
认知
鞭毛蛋白
Toll 样受体
Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats
期刊论文
NEURAL REGENERATION RESEARCH, 2012, 卷号: 7, 期号: [db:dc_citation_issue], 页码: 421-425
作者:
Wu, Haiqin
;
Wang, Huqing
;
Zhang, Bei
;
Zhang, Guilian
;
Zhang, Ru
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/10
endothelial nitric-oxide synthase
vascular dementia
puerarin
erythropoietin
hypoxia-inducible factor-1 alpha
Postnatal development of NADPH-diaphorase expression in the visual cortex of the golden hamster
期刊论文
NEURAL REGENERATION RESEARCH, 2011, 卷号: 6, 期号: 28, 页码: 2165-2170
Xu, Ying
;
Xiao, Yuemei
;
diao, yuncheng
;
刁云程
;
So, KwokFai
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  |  
浏览/下载:16/0
  |  
提交时间:2013/12/25
NADPH-diaphorase
nitric oxide synthase
postnatal development
visual cortex
area 17
golden hamster
neural regeneration
Effect of extracellular signal-regulated kinase and nitric oxide on compressive neuralgia formation and maintenance
期刊论文
NEURAL REGENERATION RESEARCH, 2010, 卷号: 5, 期号: 10
作者:
Yang, Tongwei
;
Song, Xuesong
;
Wang, Ping
;
Wang, Chunxi
;
Lu, Baoshun
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
extracellular signal-regulated kinase
nitric oxide synthase
neuropathic pain
sensitization
hyperalgesia
neural regeneration
Oxidative damage of primary cultured hippocampal neurons Does androgen have an antagonistic effect?
期刊论文
NEURAL REGENERATION RESEARCH, 2010, 卷号: 5, 期号: 5, 页码: 358-363
作者:
Li, Zhaohui[1]
;
Cai, Zhiping[2]
;
Cui, Huixian[3]
;
Zhu, Jinsong[4]
;
Li, Sha[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/21
androgen
primary cultured hippocampal neuron
free radical
nitric oxide synthase
superoxide dismutase
malondialdehyde
oxidative damage
Cervical sympathetic trunk transection affects inducible nitric oxide synthase expression in rat hippocampus following focal cerebral ischemia/reperfusion injury
期刊论文
NEURAL REGENERATION RESEARCH, 2008, 卷号: 3, 期号: 10
作者:
Xiong, Liangzhi
;
Wang, Yan
;
Wang, Qingxiu
;
Zhou, Qingshan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
brains
ischemia/reperfusion
inducible nitric oxide synthase
sympathetic trunk
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