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科研机构
复旦大学上海医学院 [17]
湖南大学 [2]
上海中医药大学 [1]
内容类型
期刊论文 [20]
发表日期
2019 [2]
2018 [1]
2017 [2]
2015 [2]
2013 [2]
2012 [2]
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A multifunctional bis--nor-meptazinol-oxalamide hybrid with metal-chelating property ameliorates Cu-induced spatial learning and memory deficits via preventing neuroinflammation and oxido-nitrosative stress in mice
期刊论文
Journal of Trace Elements in Medicine and Biology, 2019, 卷号: Vol.52, 页码: 199-208
作者:
Xiaofang Tan
;
Yan Zhou
;
Ping Gong
;
Huifeng Guan
;
Baichuan Wu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/13
Bis-(−)-nor-meptazinol-oxalamide
Hybrid
Copper
Cognitive
deficit
Neuronal
injury
Neuroinflammation
Oxido-Nitrosative
stress
A multifunctional bis--nor-meptazinol-oxalamide hybrid with metal-chelating property ameliorates Cu-induced spatial learning and memory deficits via preventing neuroinflammation and oxido-nitrosative stress in mice.
期刊论文
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2019, 卷号: Vol.52, 页码: 199-208
作者:
Xiaofang Tan
;
Yan Zhou
;
Ping Gong
;
Huifeng Guan
;
Baichuan Wu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/12/17
Bis-(−)-nor-meptazinol-oxalamide
Cognitive
deficit
Copper
Hybrid
Neuroinflammation
Neuronal
injury
Oxido-Nitrosative
stress
Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice
期刊论文
TRANSLATIONAL NEURODEGENERATION, 2018, 卷号: 7
作者:
Shi, Yuhuan
;
Huang, Wanying
;
Wang, Yu
;
Zhang, Rui
;
Hou, Lina
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Bis(9)-(-)-Meptazinol
AChE inhibitor
Alzheimer's disease
新型乙酰胆碱酯酶抑制剂Bis(9)-(-)-Meptazinol的小鼠和大鼠药代动力学研究
期刊论文
现代生物医学进展, 2017, 期号: 6
作者:
史玉欢
;
赵恒毅
;
葛新星
;
郑兆浠
;
王宇
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
Bis(9)-(-)-Meptazinol
阿尔茨海默病
药代动力学
LC-MS/MS
Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis
期刊论文
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 卷号: 32, 期号: 1
作者:
Xie, Qiong
;
Zheng, Zhaoxi
;
Shao, Biyun
;
Fu, Wei
;
Xia, Zheng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
07002, Behavioral biology - General and comparative behavior
07003, Behavioral biology - Animal behavior
10802, Enzymes - General and comparative studies: coenzymes
12512, Pathology - Therapy
20504, Nervous system - Physiology and biochemistry
20506, Nervous system - Pathology
22002, Pharmacology - General
22024, Pharmacology - Neuropharmacology
(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13
作者:
Cheng, Shaobing
;
Zheng, Wei
;
Gong, Ping
;
Zhou, Qiang
;
Xie, Qiong
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Alzheimer's disease
Multi-target-directed ligands
A beta aggregation
Antioxidant
(-)-Meptazinol-melatonin hybrids as novel dual inhibitors of cholinesterases and amyloid-beta aggregation with high antioxidant potency for Alzheimer's therapy
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 13
作者:
Cheng, Shaobing
;
Zheng, Wei
;
Gong, Ping
;
Zhou, Qiang
;
Xie, Qiong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Alzheimer's disease
Multi-target-directed ligands
A beta aggregation
Antioxidant
Theoretical and NMR investigations on the conformations of (-)-meptazinol hydrochloride in solution
期刊论文
MOLECULAR SIMULATION, 2013, 卷号: 39, 期号: 13
作者:
Li, Wei
;
Xu, Li-li
;
Xie, Qiong
;
Chen, Yan
;
Lu, Mei-yan
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/19
(-)-meptazinol hydrochloride
theoretical calculation
nuclear magnetic resonance study
conformations
Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice
期刊论文
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2013, 卷号: 104
作者:
Liu, Ting
;
Xia, Zheng
;
Zhang, Wei-Wei
;
Xu, Jian-rong
;
Ge, Xin-Xing
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/19
Bis-Mep
MTDL
Dual-binding AChE inhibitor
Cognitive amelioration
Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 卷号: 264, 期号: 1
作者:
Zheng, Wei
;
Li, Juan
;
Qiu, Zhuibai
;
Xia, Zheng
;
Li, Wei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Bis-(-)-nor-meptazinol derivatives
Acetylcholinesterase inhibitor
A beta aggregation
Metal chelation
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