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科研机构
厦门大学 [2]
复旦大学上海医学院 [2]
南华大学 [1]
上海药物研究所 [1]
中南大学 [1]
上海大学 [1]
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期刊论文 [10]
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2019 [4]
2016 [3]
2014 [1]
2013 [2]
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Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes
期刊论文
FRONTIERS IN PHYSIOLOGY, 2019, 卷号: 10
作者:
Wang, Yinhang
;
Tao, Jie
;
Wang, Mengling
;
Yang, Licai
;
Ning, Fengling
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
BK channels
mTORC2
Akt
SGK1
PKC alpha
podocyte
Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes
期刊论文
FRONTIERS IN PHYSIOLOGY, 2019, 卷号: 10
作者:
Cai, Hui
;
Wang, Yinhang
;
Tao, Jie
;
Wang, Mengling
;
Yang, Licai
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/05
BK channels
mTORC2
Akt
SGK1
PKC alpha
podocyte
Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes
期刊论文
Frontiers in physiology, 2019, 卷号: 10, 页码: 167
作者:
Wang Yinhang[1]
;
Tao Jie[2]
;
Wang Mengling[3]
;
Yang Licai[4]
;
Ning Fengling[5]
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/04/22
Akt
BK channels
PKCα
SGK1
mTORC2
podocyte
Targeting of mTORC1/2 by dihydroevocarpine induces cytotoxicity in acute myeloid leukemia
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 卷号: 234, 期号: 8
作者:
Zhang, Silin
;
Xiong, Yunhe
;
Zhang, Yixian
;
Zhao, Hongmei
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
acute myeloid leukemia (AML)
bone marrow (BM) microenvironment
dihydroevocarpine
mTOR complex 1 (mTORC1)
mTOR complex 2 (mTORC2)
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:
Qian, Jianchang
;
Chen, Yaqing
;
Meng, Tao
;
Ma, Lanping
;
Meng, Lanfang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
mTOR kinase inhibitor
mTORC2
apoptosis
lipid metabolism
mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 18
作者:
Chen, Yaqing
;
Qian, Jianchang
;
He, Qun
;
Zhao, Hui
;
Toral-Barza, Lourdes
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
mTORC2
ATP citrate lyase
lipid synthesis
breast cancer
cancer metabolism
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
期刊论文
Cellular Signalling, 2016, 卷号: 28, 期号: 8, 页码: 1099-1104
作者:
Wang, Jing
;
Yang, Xin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/03
4E-BP1
4E binding protein
AMPK
AMP-activated protein kinase
ATF6
activating transcription factor 6
ATP
adenosine triphosphate
DEPTOR
DEP domain containing mTOR-interacting protein
CI
complexes I
CII
complex II
CIII
complex III
CIV
complex IV
CV
complex V
eIF2α
Eukaryotic Initiation Factor 2α
ER
Endoplasmic Reticulum
ERAD
ER-associated degradation
ERO1α
ER oxidoreductase 1 α
FoxO1
Forkhead box O1
GβL
G Protein β Subunit Like Protein
GRP78
78 kDa glucose-regulated protein precursor
GSIS
glucose-stimulated insulin secretion
IRE1
Inositol-requiring enzyme 1
IRS1
Insulin receptor substrate 1
IRS2
Insulin receptor substrate 2
mLST8
mammalian lethal with sec-13 protein 8
mSin1
the mammalian stress-activated MAP kinase-interaction protein 1
mtDNA
mitochondrial deoxyribonucleic acid
mTOR
mammalian TOR
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
NADPH oxidase
Nicotinamide adenine dinucleotide phosphate-oxidase
NOS
nitric oxide synthase
O2–·
superoxide anion
H2O2
hydrogen peroxide
OH·
hydroxyl radical
3O2
triplet-state molecular oxygen
OXPHOS
oxidative phosphorylation
CAT
catalase
GPx
glutathioneperoxidase
PERK
Protein kinase R-like endoplasmic reticulum kinase
PDI
ER protein disulfide isomerases
PI3K
the phosphoinositide3-kinase
PRAS40
40-kDa proline-rich Akt substrate
PRAS40
the 40-kDa proline-rich Akt substrate
PROTOR
the protein observed with RICTOR
RAPTOR
regulatory-associated protein of mTOR
RICTOR
The rapamycin-insensitive companion of mTOR
REDD1
DNA damage response 1
RNS
reactive nitrogen species
ROS
reactive oxygen species
RNS
reactive nitrogen species
S6K
S6 kinase
SOD
superoxidedismutase
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TOR
the target of rapamycin
TSC2
Tuberous sclerosis 2
UPR
unfolded protein response
Mitochondrial oxidative stress
ER stress
mTOR
Pancreatic β cells
SIRT1 in cardiovascular aging
期刊论文
Clinica Chimica Acta, 2014, 卷号: 437, 页码: 106-114
作者:
Luo, Xin-Yuan
;
Qu, Shun-Lin
;
Tang, Zhi-Han
;
Zhang, Yuan
;
Liu, Mi-Hua
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/27
CVD
cardiovascular disease
SIRT1
sirtuin1
LV
left ventricular
Sir2
silent information regulator 2
rDNA
recombinant DNA
PI3K
phosphoinositide 3-hydroxykinase
NF-κB
nuclear factor kappa B
FOXOs
forkhead box O transcription factors
ROS
reactive oxygen species
mTOR
mammalian (or mechanistic) target of rapamycin
H2O2
hydrogen peroxide
NO
nitric oxide
GADD45
DNA damage-inducible protein 45
MnSOD
manganese superoxide dismutase
H2S
hydrogen sulfide
HUVECs
human umbilical vein endothelial cells
eNOS
endothelial nitric oxide synthase
miR
microRNA
CR
caloric restriction
AP-1
activator protein 1
STACs
small molecule activators of SIRT1
mTORC1
mTOR complex 1
mTORC2
mTOR complex 2
LC
light chain
IGF
insulin-like growth factor
Atgs
autophagy-related genes
SIRT1
Cardiovascular aging
Oxidative stress
Inflammation
Autophagy
Anti-aging strategies
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling
期刊论文
http://dx.doi.org/10.1002/emmm.201201369, 2013
Wang, Rong-Hao
;
He, Jian-Ping
;
Su, Mao-Long
;
Luo, Jie
;
Xu, Ming
;
Du, Xiao-Dan
;
Chen, Hang-Zi
;
Wang, Wei-Jia
;
Wang, Yuan
;
Zhang, Nan
;
Zhao, Bi-Xing
;
Zhao, Wen-Xiu
;
Shan, Zhong-Gui
;
Han, Jiahuai
;
Chang,
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2013/12/12
angiotensin II
cardiac hypertrophy
mammalian target of rapamycin
orphan receptor TR3
tuberous sclerosis complex
The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling
期刊论文
http://dx.doi.org/10.1002/emmm.201201369, 2013
Wang, Rong-Hao
;
He, Jian-Ping
;
Su, Mao-Long
;
Luo, Jie
;
Xu, Ming
;
Du, Xiao-Dan
;
Chen, Hang-Zi
;
Wang, Wei-Jia
;
Wang, Yuan
;
Zhang, Nan
;
Zhao, Bi-Xing
;
Zhao, Wen-Xiu
;
Shan, Zhong-Gui
;
Han, Jiahuai
;
Chang,Chawnshang
;
Wu,Qiao
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2013/12/12
angiotensin II
cardiac hypertrophy
mammalian target of rapamycin
orphan receptor TR3
tuberous sclerosis complex
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