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GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 941-957
作者:  Wang, Congcong;  Zhang, Yu-Fang;  Guo, Shimeng;  Zhao, Quan;  Zeng, Yanping
收藏  |  浏览/下载:22/0  |  提交时间:2021/05/24
应用鞣花酸治疗亨廷顿舞蹈病转基因小鼠的研究 学位论文
: 中国科学院大学, 2020
作者:  孙勋
收藏  |  浏览/下载:19/0  |  提交时间:2021/09/07
Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein 期刊论文
FOOD & FUNCTION, 2020, 卷号: 11, 期号: 2, 页码: 1334-1348
作者:  Sun, Xun;  Zhu, Jie;  Sun, Xiao-ying;  Ji, Mei;  Yu, Xiao-lin
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/06
HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome 期刊论文
NEUROBIOLOGY OF DISEASE, 2019, 卷号: 132, 页码: 104585
作者:  Wang, Tingting;  Wang, Jingyu;  Wang, Jie;  Mao, Lin;  Tang, Bin
收藏  |  浏览/下载:9/0  |  提交时间:2021/11/10
Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway 期刊论文
BRAIN RESEARCH, 2018, 卷号: 1697, 页码: 21-33
作者:  Liu, Shu-ying;  Yu, Xiao-lin;  Zhu, Jie;  Liu, Xiang-meng;  Zhang, Yue
收藏  |  浏览/下载:50/0  |  提交时间:2018/10/11
PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin 期刊论文
FASEB JOURNAL, 2018, 卷号: 32, 期号: 6, 页码: 2923-2933
作者:  Yang, Hui;  Yue, Hong-Wei;  He, Wen-Tian;  Hong, Jun-Ye;  Jiang, Lei-Lei
收藏  |  浏览/下载:28/0  |  提交时间:2019/04/28
Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy 期刊论文
AUTOPHAGY, 2017, 卷号: 13, 期号: 12
作者:  Sun, Xiaoli;  Fu, Yuhua;  Pan, Yuyin;  Lu, Boxun
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/05
Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models 期刊论文
CELL RESEARCH, 2017, 卷号: 27, 期号: 12
作者:  Yu, Meng;  Fu, Yuhua;  Liang, Yijian
收藏  |  浏览/下载:14/0  |  提交时间:2019/12/05
Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 493, 期号: 1, 页码: 708-717
作者:  Zheng, Ju;  Yang, Junsheng;  Choe, Young Jun;  Hao, Xinxin;  Cao, Xiuling
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/11
A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: NOV, 页码: 36631
作者:  Zha, Jun;  Liu, Xiang-meng;  Zhu, Jie;  Liu, Shu-ying;  Lu, Shuai
收藏  |  浏览/下载:26/0  |  提交时间:2016/12/26


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