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浏览/检索结果:
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
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  |  
浏览/下载:14/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Complete genome analysis of pathogenic Metschnikowia bicuspidata strain MQ2101 isolated from diseased ridgetail white prawn, Exopalaemon carinicauda
期刊论文
BMC MICROBIOLOGY, 2023, 卷号: 23, 期号: 1, 页码: 17
作者:
Shi, Wen-jun
;
Zhao, Ran
;
Zhu, Jian-qiang
;
Wan, Xi-he
;
Wang, Li-bao
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  |  
浏览/下载:12/0
  |  
提交时间:2023/11/15
Exopalaemon carinicauda
Metschnikowia bicuspidata
Complete genome sequence
Virulence genes
Metabolic mechanism
Label-free quantitative proteomics reveals the antibacterial mechanism of rosemary essential oil against Salmonella enterica serovar Typhimurium
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2022, 卷号: 189
作者:
Hao, Yuanpeng
;
Guo, Xiaoqi
;
Zhang, Wenying
;
Xia, Fei
;
Yang, Evan
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  |  
浏览/下载:2/0
  |  
提交时间:2024/03/07
Rosemary essential oil
Salmonella enterica serovar Typhimurium
Antimicrobial mechanism
Growth parameters
Proteomics
Innovative Synthesis of PANI/Cu2O Nanocomposite and Its Antibacterial Properties**
期刊论文
CHEMISTRYSELECT, 2021, 卷号: 6, 期号: 47, 页码: 13636-13641
作者:
Zhang, Mengmeng
;
Han, Sha
;
Niu, Xiaohui
;
Li, Hongxia
;
Zhang, Deyi
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  |  
浏览/下载:15/0
  |  
提交时间:2022/03/01
Antibiotics
Cuprous oxide nanoparticles
Drug resistant
Nanocomposites
Polyaniline
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64
作者:
Fu, Weitao
;
Zhang, Minkui
;
Liao, Jianing
;
Tang, Qing
;
Lei, Yixuan
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  |  
浏览/下载:56/0
  |  
提交时间:2022/03/21
Antifungal azoles and azole resistance in the environment: current status and future perspectives-a review
期刊论文
REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY, 2021, 页码: 31
作者:
Assress, Hailemariam Abrha
;
Selvarajan, Ramganesh
;
Nyoni, Hlengilizwe
;
Mamba, Bhekie B.
;
Msagati, Titus A. M.
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  |  
浏览/下载:33/0
  |  
提交时间:2021/11/16
Occurrence
Azole antifungal drugs
Azole resistance
Future perspectives
Fungi
Environment
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2021, 页码: 11
作者:
Xiong, Zhaoping
;
Cheng, Ziqiang
;
Lin, Xinyuan
;
Xu, Chi
;
Liu, Xiaohong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
federated learning
drug discovery
FedAMP
Non-IID data
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8644-8665
作者:
Kong, Qidi
;
Pan, Wei
;
Xu, Heng
;
Xue, Yaru
;
Guo, Bin
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  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
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