CORC

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CORC

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DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation 期刊论文
DIABETES, 2021, 卷号: 70, 期号: 6, 页码: 1317-1333
作者:  Shuai, Lin;  Li, Bo-Han;  Jiang, Hao-Wen;  Yang, Lin;  Li, Jia
收藏  |  浏览/下载：22/0  |  提交时间：2021/08/17
Design, Synthesis, and Biological Activities of Novel Triazolothiadiazole Derivatives Linked with Amino Side Chain Containing Urea Group as DOT1L Inhibitors 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 8, 页码: 2450-2459
作者:  Liu Na;  Guo Siqi;  Liu Junfang;  Chen Yantao;  Xu Xiaoming
收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24
Structural Modifications of the Triazolo-thiadiazole Derivatives as DOT1L Inhibitors and Their Activities 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 5, 页码: 1345-1354
作者:  Xu Xiaoming;  Guo Siqi;  Zhang Jing;  Chen Yantao;  Kang Yaqing
收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24
Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758
作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao
收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
组蛋白赖氨酸甲基转移酶DOT1L抑制剂分子水平高通量筛选模型的建立 期刊论文
上海大学学报（自然科学版）, 2018, 卷号: 24, 页码: 126-133
作者:  徐威[1];  苏明波[2];  周宇波[3]
收藏  |  浏览/下载：3/0  |  提交时间：2019/04/24
Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOTI L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-L-methionine (SAM)-Dependent Methyltransferase Family 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 2026-2036
作者:  Wang, Yulan;  Li, Linjuan;  Zhang, Bidong;  Xing, Jing;  Chen, Shijie
收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08
Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534
作者:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu
收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08
Epigenetic targets and drug discovery: Part 1: Histone methylation 期刊论文
Pharmacology and Therapeutics, 2014, 卷号: 143, 期号: 3, 页码: 275-294
作者:  Liu, Yanli;  Liu, Ke;  Qin, Su;  Xu, Chao;  Min, Jinrong*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/23
Epigenetics  Histone methylation  Inhibitor  Chemical probe  Cancer  PTM  posttranslational modification  HMTs  histone methyltrans-ferases  SET  Suv39, E(z) and Trithorax  SUV39  Su(var)3-9  SUV420  histone-lysine N-methyltransferase SUV420  G9a  euchromatic histone-lysine N-methyltransferase 2  GLP  G9a-like protein 1  Wiz  widely-interspaced zinc finger-containing protein  CDYL1  chromodomain Y-like protein  ACIN1  apoptotic chromatin condensation inducer in the nucleus  SAH  S-adenosyl-l-homocysteine  l  SAM  S-adenosylmethionine  Dot1  disruptor of telomeric silencing  Dot1L  DOT1-Like protein  EZH1  Enhancer of zeste homolog 1  EZH2  Enhancer of zeste homolog 2  Hox  homeotic box  PcG  Polycomb group  PRC1  Polycomb Repressive Complex 1  PRC2  Polycomb Repressive Complex 2  DZNep  3-Deazan- eplanocin A  SMYD2  SET and MYND domain-containing protein 2  PRMT  protein arginine methyltransferases  AMI-1  arginine methyltransferase inhibitor-1  MBT  Malignant Brain Tumor  PEV  position-effect variegation  HSPC  hematopoietic stem and progenitor cells  ChIP  chromatin immunoprecipitation  PK  pharmacokinetic  

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