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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Biological Eagle-eye Inspired Target Detection for Unmanned Aerial Vehicles Equipped with a Manipulator
期刊论文
Machine Intelligence Research, 2023, 卷号: 20, 期号: 5, 页码: 741-752
作者:
Yi-Min Deng, Si-Yuan Wang
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  |  
浏览/下载:3/0
  |  
提交时间:2023/09/25
Unmanned aerial vehicle (UAV), eagle eye, multi-camera sensor, target detection, saliency detection
Biological Eagle-eye Inspired Target Detection for Unmanned Aerial Vehicles Equipped with a Manipulator
期刊论文
Machine Intelligence Research, 2023, 卷号: 20, 期号: 5, 页码: 741-752
作者:
Yi-Min Deng
;
Si-Yuan Wang
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  |  
浏览/下载:0/0
  |  
提交时间:2024/04/23
Unmanned aerial vehicle (UAV), eagle eye, multi-camera sensor, target detection, saliency detection
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wang, Zuo-wei
;
Zou, Feng-ming
;
Wang, Ao-li
;
Yang, Jing
;
Jin, Rui
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  |  
浏览/下载:21/0
  |  
提交时间:2022/12/22
AZD4547
RIPK1
inhibitors
SIRS model
anti-necroptosis
Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues
期刊论文
CELL DISCOVERY, 2022, 卷号: 8
作者:
Bo, Qing
;
Yang, Fan
;
Li, Yingge
;
Meng, Xianyu
;
Zhang, Huanhuan
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  |  
浏览/下载:11/0
  |  
提交时间:2022/12/23
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Cao, Jiang-yan
;
Qi, Shuang
;
Wu, Hong
;
Wang, Ao-li
;
Liu, Qing-wang
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  |  
浏览/下载:95/0
  |  
提交时间:2022/03/28
HER2
breast cancers
gastric cancers
irreversible inhibitor
drug resistance
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
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  |  
浏览/下载:80/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
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  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Nanocrystal-loaded liposome for targeted delivery of poorly water-soluble antitumor drugs with high drug loading and stability towards efficient cancer therapy
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 599
作者:
Liang, Huamin
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Fu, Liyi
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  |  
浏览/下载:68/0
  |  
提交时间:2021/05/17
Liposome
Drug nanocrystal
Core-shell
Drug delivery
Tumor therapy
BCR-ABL
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975
作者:
Zhang, Hefeng
;
Peng, Xia
;
Dai, Yang
;
Shao, Jingwei
;
Ji, Yinchun
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  |  
浏览/下载:17/0
  |  
提交时间:2021/06/11
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