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BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer
期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:
Lv, Yang
;
Lv, Xiaotong
;
Zhang, Jiahui
;
Cao, Guozhen
;
Xu, Changzhi
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/05/16
small cell lung cancer
BRD4
KEAP1
Nrf2
pentose phosphate pathway
Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma
期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:
Chen, Zi-qi
;
Cao, Zhe-rui
;
Wang, Yi
;
Zhang, Xi
;
Xu, Lan
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2021/12/16
CYH33
MYC
P300
BET
B cell lymphoma
PI3K
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12075-12088
作者:
Lu, Tian
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  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
期刊论文
GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069
作者:
Liu, Yuwei
;
Xue, Mengzhu
;
Cao, Danyan
;
Qin, Lihuai
;
Wang, Ying
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  |  
浏览/下载:33/0
  |  
提交时间:2021/08/17
Multi-omics
BET inhibitor responses
WNT pathway
Liver cancer
Precise therapy
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:
Wu, Qian
;
Chen, Dan-Qi
;
Sun, Lin
;
Huan, Xia-Juan
;
Bao, Xu-Bin
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  |  
浏览/下载:118/0
  |  
提交时间:2021/05/24
N2817
Bivalent BET inhibitors
Monovalent BET inhibitors
TAF1
Anticancer activity
Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer
期刊论文
NANO TODAY, 2021, 卷号: 36, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Xu, Zhiai
;
Li, Tianliang
;
Gao, Ang
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  |  
浏览/下载:27/0
  |  
提交时间:2021/06/11
Tumor microenvironment
Prodrug nanovesicles
Cancer immunotherapy
Immunogenic cell death
Adaptive immune resistance
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
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  |  
浏览/下载:31/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer
期刊论文
ADVANCED SCIENCE, 2021, 页码: 12
作者:
Sun, Fang
;
Zhu, Qiurong
;
Li, Tianliang
;
Saeed, Madiha
;
Xu, Zhiai
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  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
glucose metabolism
immunogenic cell death
pancreatic cancer
photoimmunotherapy
prodrug nanoparticles
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
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