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浏览/检索结果: 共4条，第1-4条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Key Considerations in Targeted Protein Degradation Drug Discovery and Development 期刊论文 FRONTIERS IN CHEMISTRY, 2022, 卷号: 10 作者:  Qin, Liena;  Dai, Han;  Wang, Junfeng 收藏  |  浏览/下载：25/0  |  提交时间：2022/12/23 targeted protein degradation  PROTAC  molecular glue  chemically induced proximity  drug discovery and development   The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 149, 页码: 148-169 作者:  Peng, Dian;  Cao, Bin;  Zhou, Ying-Jun;  Long, Ya-Qiu 收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 CXC chemokine receptor 4  Small molecule antagonists  Structure-based optimization  HIV-1 entry  Tumor metastasis  Inflammation  Ischemia-reperfusion  Autoimmune   Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition 期刊论文 Toxicology in Vitro, 2009 作者:  Wang C;  Li S;  Wang MW. 收藏  |  浏览/下载：4/0  |  提交时间：2019/02/27 Anti-Inflammatory  Agents,  Non-Steroidal/*pharmacology  Antineoplastic  Agents  Biotransformation/drug  effects  Blotting,  Western  Caspases/*physiology  Cell  Death/drug  effects  Cell  Line,  Tumor  Cell  Survival  Coloring  Agents  Extracellular  Signal-Regulated  MAP  Kinases/antagonists  &  inhibitors/metabolism  Fas  Ligand  Protein/biosynthesis/*physiology  Humans  Melanoma,  Experimental/*drug  therapy/pathology  NF-kappa  B/antagonists  &  inhibitors/metabolism/*physiology  Oncogene  Protein  v-akt/*physiology  Phosphatidylinositol  3-Kinases/*physiology  Plant  Extracts/*pharmacology  Proteasome  Inhibitors  Proto-Oncogene  Proteins  c-bcl-2/metabolism  Quinazolines/*pharmacology  Signal  Transduction/drug  effects  Tetrazolium  Salts  Thiazoles  Ubiquitin/*antagonists  &  inhibitors   EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation 期刊论文 2008 Ding, W.; Li, C. X.; Hu, T. H.; Graves-Deal, R.; Fotia, A. B.; Weissman, A. M.; Coffey, R. J.; 胡天惠 收藏  |  浏览/下载：1/0  |  提交时间：2013/12/12 AO7/RNF25  E3 ligase  Wnt antagonist