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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 263, 页码: 19
作者:
Wang, Chaogang
;
Du, Mingyang
;
Jiang, Zhuxiang
;
Cong, Rihao
;
Wang, Wei
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/12/13
Heat stress
Oysters
Crassostrea angulata
Crassostrea gigas
Phosphorylation
Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:
Liang, Xiaofei
;
Wang, Chun
;
Wang, Beilei
;
Liu, Juan
;
Qi, Shuang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/12/23
CSF1R inhibitor
Kinase inhibitor
Macrophage polarization
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis
期刊论文
BIOACTIVE MATERIALS, 2022, 卷号: 17, 页码: 406-424
作者:
Wang, Jin
;
Xie, Si-an
;
Li, Ning
;
Zhang, Tao
;
Yao, Weijuan
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  |  
浏览/下载:107/0
  |  
提交时间:2022/06/10
Matrix stiffness
Inflammation
DDR1
DNMT1
Mechanotransduction
Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
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  |  
浏览/下载:81/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 7, 页码: 3956-3975
作者:
Zhang, Hefeng
;
Peng, Xia
;
Dai, Yang
;
Shao, Jingwei
;
Ji, Yinchun
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  |  
浏览/下载:17/0
  |  
提交时间:2021/06/11
Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A
期刊论文
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2020, 卷号: 80, 页码: 1-8
作者:
Zhang, Xiaoru
;
Zhang, Yaxian
;
Ji, Zhihua
;
Wang, Fengbang
;
Zhang, Lei
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/09/14
Tetrachlorobisphenol A
Reactive oxygen species accumulation
Signaling pathway
Saccharomyces cerevisiae
Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 页码: 14
作者:
Mutharasu, Gnanavel
;
Murugesan, Akshaya
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/10
GPR17
signaling networks
glioblastoma multiforme
RNA-Seq
protein–
protein interface
kinases
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737
作者:
Li, Xutong
;
Li, Zhaojun
;
Wu, Xiaolong
;
Xiong, Zhaoping
;
Yang, Tianbiao
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/12/21
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